THE FEATURES OF BONE METABOLISM IN MULTIPLE MYELOMES AT THE PATIENTS WITH DIFFERENT TYPES OF CHEMIOTHEREPY

Abstract

One of the basic links pathogenesis of MM is osteolytic defeats of a bone fabric. At the heart of this process lies inhibition osteoblast activity and increased osteoclast activity. At 80 % of patients decrease in mineral density of a bone fabric in a combination with individual or plural bone lesions and pathological fractures takes place. Late diagnostics low mineral density can lead to development of the driven crises of the vertebras, raised mobility of disks with development of a compression of a spinal cord and neurologic semiology. For MM spontaneous easily arising crises of bones are characteristic, therefore frequently patients from MM arrive in hematological branches after inspection and treatment at the traumatologist. In the program of treatment of MM the special role belongs to appointment of preparations from group bisphosphonates. Patients from MM should receive cyclic long (not less than 2th years) preventive treatment bisphosphonates for the prevention of pathological crises, in independence of presence or absence of an osteoporosis.