Immunohistohemical ASSESSMENT of E-cadherin expression AT ovarian cancer
https://doi.org/10.51523/2708-6011.2009-6-1-11
Abstract
Expression of E-cadherin was investigated with immunohistochemical method in 65 cases of primary ovarian carcinoma. E-cadherin levels depended on cell differentiation, FIGO stage, pre-sence of metastases and five-year survival.
About the Authors
A. V. Shulha
Grodno State Medical University
Belarus
Belarus
V. A. Basinsky
Grodno State Medical University
Belarus
Belarus
S. A. Lalikov
Grodno State Medical University
Belarus
Belarus
S. E. Savitsky
Grodno State Medical University
Belarus
Belarus
References
1. Аничков, Н. М. Биологические и клинико-морфологические аспекты учения о метастазировании злокачественных опухолей / Н. М. Аничков // Мед. академ. журнал. - 2003. - Т. 3, № 1. - C. 3-13.
2. Жорданина, К. И. Некоторые аспекты хирургического лечения рака яичников / К. И. Жорданина // Практ. онкол. - 2000. - № 4. - C. 19-22.
3. Эпидемиология злокачественных новообразований в Беларуси / И. В. Залуцкий [и др.]. - М.: Зорны верасень, 2006. - 207 с.
4. Малек, А. В. Поиск генов-мишеней для диагностики и терапии рака яичников / А. В. Малек, Е. В. Бахидзе // Вопросы онкологии. - 2005. - Т. 51, № 2. - С. 182-186.
5. Новик, А. А. Введение в молекулярную биологию канцерогенеза / А. А. Новик, Т. А. Камилова, В. Н. Цыган. - М.: ГЭОТАР МЕД, 2004. - 224 с.
6. The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients / K. Blechschmidt [et al.] // British Journal of Cancer. - 2008. Vol. 98. - P. 489-495.
7. ß-Catenin expression pattern in stage I and II ovarian сarcinomas relationship with ß-catenin gene мutations, clinicopathological features, and clinical outcome / C. Gamallo [et al.] // American Journal of Pathology. - 1999. - Vol. 155. - P. 527-536.
8. Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas / T. Imai [et al.] // Hum Pathol. - 2004. -Vol. 35. - P. 1469-1476.
9. Lim, S. C. Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancer / S. C. Lim, S. M. Lee // Oncol Rep. - 2002. - Vol. 9, № 5. - P. 915-928.
10. Mareel M. Clinical, сellular, and мolecular аspects of сancer invasion / M. Mareel, A. Leroy // Physiol Rev. - 2003. - Vol. 83. - P. 337-376.
11. Immunohistochemical patterns for alpha- and beta-catenin, E- and N-cadherin expression in ovarian epithelial tumors / F. R. Marques [et al.] // Gynecol Oncol. - 2004. - Vol. 94. - P. 16-24.
12. Ozols, R. F. Treatment goals in ovarian cancer / R. F. Ozols // Int J Gynerol Cancer. - 2005. - Vol. 15, № 1. - P. 3-11.
13. Global cancer statistics, 2002 / D. M. Parkin [et al.] // CA Cancer J Clin. - 2005. - Vol. 55. - P. 74-108.
14. Prognostic significance of E-cadherin-catenin complex in epithelial ovaian cancer / K. A. Voutilainen [et al.] // J Clin Pathol. - 2006. - Vol. 59. - P. 460-467.
15. Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival / Y. N. Zhou [et al.] // World J Gastroenterol. - 2002. - Vol. 8. - P. 987-993.
Review
For citations:
Shulha A.V., Basinsky V.A., Lalikov S.A., Savitsky S.E. Immunohistohemical ASSESSMENT of E-cadherin expression AT ovarian cancer. Health and Ecology Issues. 2009;(1):58-61. (In Russ.) https://doi.org/10.51523/2708-6011.2009-6-1-11
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