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POSSIBILITIES OF FORECASTING OF CHILD IDIOPATIC THROMBOCYTOPENIC PURPURA VARIANT

https://doi.org/10.51523/2708-6011.2008-5-4-13

Abstract

The clinico-immunological survey of 109 children at the age of from 2 months to 15 years suffered from idiopathic thrombocytopenic purpura (ITP) has been conducted. In the course of verification of the diagnosis, in order to evaluate trombocytopoiesis, the method of flow cytometry was used to detect the level of young forms of platelets marked with thiazole-orange. The misbalance of immune status at child ITP was detected which is characterized by T-cell link suppression (CD3+) due to T-helpers (CD4+) and T-active lymphocytes (CD3+HLA-DR+) and excessive activation of B-cell link (CD19+). Acute ITP presented in 65 % of cases, chronical one - in 35 %.Possible prognostic clinico-immunological criteria of ITP variant have been detected.

About the Authors

S. A. Hoduleva
Gomel State Medical University
Belarus


I. P. Romashevskaya
Republican Research Centre of Radiation Medicine and Human Ecology
Belarus


References

1. Ходулева, С. А. Распространенность и структура заболеваемости идиопатической тромбоцитопенической пурпурой у детей Гомельской области Республики Беларусь / С. А. Ходулева, Т. И. Козарезова // Гематология и трансфузиология. - 2005. -Т. 50, № 2. - С. 25-28.

2. Ходулева, С. А. Первичная аутоиммунная тромбоцитопеническая пурпура у детей / С. А. Ходулева, Т. И. Козарезова. - Гомель, 2002. - 24 с.

3. Румянцев, А. Г. Практическое руководство по детским болезням / А. Г. Румянцев, Е. В. Самочатова. - М.: Медпрактика, 2002. - Т. 4. - С. 373-417.

4. Gadner, H. Chronic Idiopathic thrombocytopenic purpura: incidence, treatmend and outcome / Н. Gadner // Clin. Exp. Hematol. - 2001. - Vol. 53. - P. 201-221.

5. Донюш, Е. К. Дифференциальная диагностика и современная тактика терапии идиопатической тромбоцитопенической пурпуры у детей / Е. К. Донюш, А. А. Масчан. - М., 2001. - 38 с.

6. Иванов, В. Е. Метод оценки состояния тромбоцитопоэза в условиях тромбоцитопении: метод. рекомендации / В. Е. Иванов, К. В. Сальников, Т. Н. Башманова. - Мн., 1999. - 14 с.


Review

For citations:


Hoduleva S.A., Romashevskaya I.P. POSSIBILITIES OF FORECASTING OF CHILD IDIOPATIC THROMBOCYTOPENIC PURPURA VARIANT. Health and Ecology Issues. 2008;(4):65-69. (In Russ.) https://doi.org/10.51523/2708-6011.2008-5-4-13

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)