SOME FINDINGS OF MICROCIRCULATION AND ENDOTHELIAL DAMAGE IN ESTIMATION OF RISK FOR STROKES, MYOCARDIAL INFARCTIONS, LETHAL OUTCOMES IN HYPERTENSIVE PATIENTS
https://doi.org/10.51523/2708-6011.2008-5-4-3
Abstract
Objective: to determine factors, associated with increased risk for development of strokes, myocardial infarctions, lethal outcomes in patients with arterial hypertension (AH) II degree. Methods: 220 patients with AH II degree (mean age 57 ± 8,4 years), complicated by hypertensive crisis, and 30 persons without AH (mean age 53,7 ± 9 years) were followed-up for 3,3±1 years. Results: elevation of number of circulating endothelial cells (CEC), aggregation of platelets and leukocytes, adhesion of leukocytes in hypertensive patients were associated with increased risk for development of strokes, myocardial infarctions, lethal outcomes. Conclusion: it’s possible to use such findings as number of circulating endothelial cells, aggregation of platelets and leukocytes, adhesion of leukocytes for determination of high risk group of hypertensive patients and creation of prognostic models.
About the Authors
V. I. Kozlovsky
Vitebsk Statel Medical University
Belarus
Belarus
A. V. Akulionak
Vitebsk Statel Medical University
Belarus
Belarus
References
1. Козловский, В. И. Активация лейкоцитов, роль в повреждении эндотелия и развитии сердечно-сосудистой патологии / В. И. Козловский, А. В. Акулёнок // Вестник ВГМУ. - 2005. - Т. 4, № 2. - С. 5-13.
2. Козловский, В. И. Повреждение эндотелия как фактор, ведущий к активации лейкоцитов и тромбоцитов у больных сердечно-сосудистыми заболеваниями / В. И. Козловский, А. В. Акулёнок // Вестник фармации. - 2005. - № 2. - С. 82-89.
3. Состояние микроциркуляции при гипертонической болезни / В. И. Маколкин [и др.] // Кардиология. - 2003. - Т. 43, № 5. - С. 60-68.
4. Диагностическая ценность определения десквамированных эндотелиальных клеток в крови / Н. Н. Петрищев [и др.] // Клин. лаб. диагн. - 2001. - № 1. - С. 50-52.
5. Modulation of endothelial nitric oxide synthase expression by red blood cell aggregation / O. K. Baskurt [et al.] // Am. J. Physiol. Heart Circ. Physiol. - 2004. - Vol. 286. - P. 222-229.
6. Blann, A. D. Endothelial cell activation, injury, damage and dysfunction: separate entities or mutual terms? / A. D. Blann // Blood Coagul. Fibrinolysis. - 2000. - Vol. 11. - P. 623-630.
7. Born, G. V. R. Aggregation of blood platelets by adenosine diphosphate and its reversal / G. V. R. Born // Nature. - 1962. - Vol. 194. - P. 927-929.
8. Endothelial cells in physiology and in the pathophysiology of vascular disorders / D. B. Cines [et al.] // Blood. - 1998. - Vol. 1. - P. 3527-3561.
9. Dignat-George, F. Circulating endothelial cells in vascular disorders: new insights into an old concept / F. Dignat-George, J. Sampol // Eur. J. Haematol. - 2000. - Vol. 65. - P. 215-220.
10. Hladovec, J. Circulating endothelial cells as a sign of vessel wall lesions / J. Hladovec // Physiol. Bohemoslov. - 1978. - Vol. 27, № 2. - Р. 140-144.
11. Kannel, W. B. Contribution to the Framingham study to preventive cardiology / W. B. Kannel // J. Am. Coil. Cardiol. - 1990. - Vol. 15. - P. 206-210.
12. Mazzoni, M. C. Mechanisms and consequences of cell activation in the microcirculation / M. C. Mazzoni, G. W. Schmid-Schonbein // Cardiovasc. Res. - 1996. - Vol. 32, № 4. - P. 709-719.
13. Stefanec, T. Endothelial apoptosis. Could it have a role in the pathogenesis and treatment of disease? / T. Stefanec // Chest. - 2000. - Vol. 274. - P. 908-913.
14. Vanhoutte, P. M. How to assess endothelial function in human blood vessels / P. M. Vanhoutte // J. Hypertens. - 1999. - Vol. 17, № 8. - Р.1047-1058.
15. WHO/ISH Hypertension Guidelines. - WHO, 1999. - P. 1-12.
Review
For citations:
Kozlovsky V.I., Akulionak A.V. SOME FINDINGS OF MICROCIRCULATION AND ENDOTHELIAL DAMAGE IN ESTIMATION OF RISK FOR STROKES, MYOCARDIAL INFARCTIONS, LETHAL OUTCOMES IN HYPERTENSIVE PATIENTS. Health and Ecology Issues. 2008;(4):19-23. (In Russ.) https://doi.org/10.51523/2708-6011.2008-5-4-3
Views: 268
Email this article 