PRODUCTION IFN-g AND IL-4 BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF CHILDREN WITH BRONCHIAL ASTHMA RECEIVING RIBOMUNYL AND «TEOTARD» + RIBOMUNYL THERAPY
https://doi.org/10.51523/2708-6011.2007-4-4-3
Abstract
The aim of research: to study the influence of immunization of children by ribomunyl and the combined application of «teotard» (theophylline) + ribomunyl on IFN-g/IL-4 ratio in PBMCs culture in children with bronchial asthma (BA). Materials and methods. 90 children with BA were divided in 2 groups. 1st group (60 children received ribomunyl) was subdivided into two subgroups on the basis of tuberculine intraskin tests: subgroup A included 30 children with normergy; subgroup B - 30 children with anergy. 2nd group included 30 children who received «teotard» during 2 weeks, and then - ribomunyl. IL-4 and IFN-g production in PBMCs culture with mytogens and without stimulation was assessed by ELISA. Results. After the completion of the therapy indicated the reliable increase of IFN-g/IL-4 ratio in both stimulated and unstimulated cultures was registered in group 1 A. In group 1 B IFN-g/IL-4 ratio remained significantly reduced (р <0,05). In group 2 IFN-g/IL-4 ratio was also reliably increased. Conclusions. Influence of ribomunyl on IL-4 and IFN- g synthesis by PBMCs in vitro, depends on an initial condition of immune system of children. Administration of a prolonged theophylline preparation "teotard" and the subsequent immunization with ribomunyl renders positive regulatory effect on immune cells functioning in children with BA, having an anergy condition.
Keywords
Бронхиальная астма,
рибомунил,
теотард,
дети,
Bronchial asthma,
ribomunyl,
teotard,
children,
anergy
About the Authors
T. G. Adamovich
Belarus State Medical University
Belarus
Belarus
L. P. Titov
Belarus State Medical University
Belarus
Belarus
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For citations:
Adamovich T.G., Titov L.P. PRODUCTION IFN-g AND IL-4 BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF CHILDREN WITH BRONCHIAL ASTHMA RECEIVING RIBOMUNYL AND «TEOTARD» + RIBOMUNYL THERAPY. Health and Ecology Issues. 2007;(4):17-21. (In Russ.) https://doi.org/10.51523/2708-6011.2007-4-4-3
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