THE ROLE OF ADRENAL CORTEX FUNCTIONAL ACTIVITY IN REGULATION OF BLOOD LIPOPROTEINS CHOLESTEROL CONTENT IN RATS AT BACTERIAL ENDOTOXINEMIA

It was established experimentally on rats that bacterial endotoxinemia of various origins, caused by pyrogenal injection and by CLP-peritonitis, was accompanied by disturbance of temperature homeostasis, activation of adrenal cortex and atherogenic changes in cholesterol content of blood lipoproteins: decrease of the amount of high density lipoprotein (HDL) cholesterol and increase of low and very low density lipoprotein (LDL and VLDL) cholesterol blood levels. Injection of exogenous glucocorticoid prednizolone during pyrogenal action prevents the decrease of the amount of HDL cholesterol but strengthens the increase of LDL and VLDL cholesterol blood levels. Activation of adrenal cortex at bacterial endotoxinemia is accompanied by inhibition of the negative feed-back mechanism in hypothalamic-pituitary-adrenal axis, what provides high activity of steroidogenesis during systemic inflammation.

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