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Letterer-Siwe disease

https://doi.org/10.51523/2708-6011.2018-15-2-20

Abstract

The article describes a case of Letterer-Siwe disease (Langerhans cells histocytosis, histiocytosis X) in a 1-year-old infant, presents the authors` own observations focusing on the macroscopic and histological picture of skin lesions. The work also notes difficulties of diagnosis of this disease. Reliable morphological features of Letterer-Siwe disease were revealed during the histologic examination of the skin.

About the Authors

I. F. Shalyga
Gomel State Medical University
Belarus


G. V. Tishchenko
Gomel State Medical University
Belarus


L. A. Martemyanova
Gomel State Medical University
Belarus


S. Yu. Turchenko
Gomel Regional Clinical Pathoanatomical Bureau
Belarus


Yu. N. Avizhets
Gomel Regional Clinical Pathoanatomical Bureau
Belarus


References

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2. Da Costa CE, SzuhaiK, van Eijk R. No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies. Genes Chromosomes Cancer. 2009;48:239-249.

3. Calonje E, Brenn T, Lazar A, McKee PH. McKee's pathology of the skin: with clinical correlations. 4th ed. Saunders: Elsevier; 2012. р.1392-1397.

4. Coury F, Annels N, Rivollier A, et al. Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat Med. 2008;14(1):81-87.

5. Fletcher CDM. Diagnostic histopathology of tumor in 2 vol. 4th ed. Saunders: Elsevier; 2013. vol.2. p. 1459-1461.

6. Folpe AL, Inwards CY. Bone and soft tissue pathology. Saunders: Elsevier, 2015. p. 437-441.


Review

For citations:


Shalyga I.F., Tishchenko G.V., Martemyanova L.A., Turchenko S.Yu., Avizhets Yu.N. Letterer-Siwe disease. Health and Ecology Issues. 2018;(2):99-103. (In Russ.) https://doi.org/10.51523/2708-6011.2018-15-2-20

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)