TAURINE AND ETHANOL IN CENTRAL NERVOUS SYSTEM: POSSIBLITY MECHANISMS INTERACTIONS
https://doi.org/10.51523/2708-6011.2006-3-2-20
Abstract
Taurine and ethanol have the positive allosteric modulatory effects on the glycine- and GABA-receptors (chloride canals) and inhibit other ligand- and voltage-dependent cation channels. Taurine may dose-dependent the ethanol-induced changes in locomotor activity, sedation and motivation. Ethanol raise the extracellular taurine levels in various brain regions, possible because of its enhanced transfer through the blood-brain barrier. Exogenous taurine, its derivatives and analogues decrease the ethanol consumption. Thus, the system of taurine homeostasis may serve as an important modulator of ethanol-induced effects in CNS.
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Review
For citations:
Sheibak V.M. TAURINE AND ETHANOL IN CENTRAL NERVOUS SYSTEM: POSSIBLITY MECHANISMS INTERACTIONS. Health and Ecology Issues. 2006;(2):103-107. (In Russ.) https://doi.org/10.51523/2708-6011.2006-3-2-20
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