THE EXTENT AND SEVERITY OF LIVER HISTOLOGICAL CHANGES IN PATIENTS WITH CHRONIC HEPATITIS C

The extent and severity of histological changes in liver specimens in 76 patients with chronic hepatitis С (CHC) depending on biochemical activity were evaluated. In patients with CHC of moderate activity more often periportal necrosis, periportal inflammation, acidophilic Councilman bodies, destruction or proliferation of biliary ducts were found. We met balloon dystrophy, fibrosis with formation of porto-septal septs and false lobules only in patients with moderate activity. The majority of compared morphological changes were more expressed in CHC patients with moderate activity, but only inflammatory infiltration of portal tracts was significantly higher.

1. Серов В.В., Севергина Л.О., Попова И.В., Игнатова Т.М. // Рос. журн. гепатол. и гастроэнтерол. - 1995 - № 3. - С. 58-61.

2. Серов В.В., Севергина Л.О. Морфологические критерии оценки этиологии, степени активности и стадии процесса при вирусных хронических гепатитах В и С. / Архив патологии. - 1996. - № 4. - С. 61-64.

3. Хронический вирусный гепатит / Под ред. В.В. Серова, З.Г. Апросиной. - М.: Медицина, 2002. - 384 с.: ил.

4. Desmet V.J., Gerber M., Hoofnagle J.H. et al. Classification of Chronic Hepatitis: Diagnosis, Grading and Staging // Hepatology. - 1994. - Vol. 19. - № 6 - P. 1513-1520.

5. Perrilo R.P. Role of liver biopsy // National Inst. of Health Conference on Hepatitis C. - Bethesda, Maryland, 1997.