Gut microbiota in immunosuppressive therapy in patients after allogeneic hemoietic stem cell transplantation
https://doi.org/10.51523/2708-6011.2025-22-1-05
Abstract
Objective. To make associations between the composition of the gut microbiota and the dosage of immunosuppressive drugs in patients after allogeneic hematopoietic stem cell transplantation.
Materials and methods. In this study, we studied the composition of the gut microbiota using the V3-V4 sequencing method of the 16S rRNA gene in 36 patients after allogeneic hematopoietic stem cell transplantation with various types of immunosuppression.
Results. Use of Tacrolimus significantly reduced the abundance of bacteria like Bacteroidetes and particularly Bacteroidaceae family in stool samples compared to cyclosporine A; patients with higher Akkermansia abundance more often required immunosuppression dose reduction to maintain target serum levels, as confirmed by two multivariate methods, while patients with higher Faecalibacterium, Oscillibacter, and Hungatella density had a higher median cyclosporine A dose to maintain therapeutic concentrations.
Conclusion. Additional studies are necessary to identify the relationship between gut microbiome and immunosuppressant drugs taking into account variable concentrations of calcineurin inhibitors, potential adverse events associated with insufficient or excessive serum drug levels, and the associations found between patients’ gut microbiome abundance and immunosuppressant dose
Supporting agencies: Republican budget; Extra-budgetary funds of the Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology
About the Authors
M. A. Uss
Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology
Belarus
Belarus
Mikhail A. Uss - Haematologist (Head) at the Hematology Department of Bone Marrow Transplantation No. 2.
Minsk
I. O. Stoma
Gomel State Medical University
Belarus
Belarus
Igor O. Stoma - Doctor of Medical Sciences, Professor.
Gomel
N. F. Milanovich
Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology
Belarus
Belarus
Natalya F. Milanovich - Candidate of Medical Sciences, Head of the Hematology Department of Bone Marrow Transplantation No. 3.
Minsk
T. N. Gubanova
Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology
Belarus
Belarus
Tatyana N. Gubanova - Researcher at the Scientific Department.
Minsk
A. L. Uss
Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology
Belarus
Belarus
Anatoly L. Uss - Doctor of Medical Sciences, Professor, Deputy Director for Hematology.
Minsk
A. A. Kovalev
Gomel State Medical University
Belarus
Belarus
Alexey A. Kovalev - Senior Lecturer at the Department of Medical and Biological Physics.
Gomel
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Review
For citations:
Uss M.A., Stoma I.O., Milanovich N.F., Gubanova T.N., Uss A.L., Kovalev A.A. Gut microbiota in immunosuppressive therapy in patients after allogeneic hemoietic stem cell transplantation. Health and Ecology Issues. 2025;22(1):39-49. (In Russ.) https://doi.org/10.51523/2708-6011.2025-22-1-05
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