Chondroid lipoma of soft tissue: immunohistochemical study
https://doi.org/10.51523/2708-6011.2025-22-1-17
Abstract
This article presents a clinical case of a rare soft tissue tumor, chondroid lipoma of the right leg, characterized by a complex morphological structure with myxoid areas, lipoblast-like cells, and zones of ossification. Despite histological similarities with chondroblastoma, parosteal osteochondromatous proliferation, myxoid liposarcoma, and chondrosarcoma, immunohistochemical (IHC) analysis and correlation with clinical and instrumental data allowed these pathological processes to be excluded.
Chondroid lipoma is a rare benign tumor, and its complex structure and potential for ossification can pose significant challenges in differential diagnosis. This case emphasizes the importance of a comprehensive approach, combining morphological, clinical, and imaging data, for the accurate diagnosis of rare bone and soft tissue tumors.
Keywords
chondroid lipoma,
soft tissue,
myxoid tumor,
ossification,
immunohistochemistry,
differential diagnosis,
H3K36M
Supporting agencies: This study was conducted without sponsorship
About the Authors
V. V. Grishakov
Moscow Oncology Hospital No. 62 of the Healthcare Department of Moscow city
Russian Federation
Russian Federation
Viktor V. Grishakov - Pathologist, Moscow Oncology Hospital No. 62 of the Healthcare Department of Moscow city; Specialist at the Scientific Research Institute of Healthcare Organization and Medical Management of the Healthcare Department of Moscow city.
Moscow
G. V. Tishchenko
Gomel State Medical University
Belarus
Belarus
Grigorii V. Tishchenko - Candidate of Medical Sciences, Associate Professor at the Department of Pathological Anatomy.
Gomel
V. N. Tishchenko
Gomel Regional Clinical Pathological Bureau
Belarus
Belarus
Vera N. Tishchenko – Pathologist.
Gomel
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Supplementary files
Review
For citations:
Grishakov V.V., Tishchenko G.V., Tishchenko V.N. Chondroid lipoma of soft tissue: immunohistochemical study. Health and Ecology Issues. 2025;22(1):137-144. (In Russ.) https://doi.org/10.51523/2708-6011.2025-22-1-17
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