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Crohn’s disease as a debut of common variable immunodeficiency

https://doi.org/10.51523/2708-6011.2024-21-1-15

Abstract

   The article presents a case of common variable immunodeficiency without clinically significant infectious syndrome with manifestation in the form of Crohn’s disease. The article emphasizes the expediency of including in the complex of examination in chronic inflammatory diseases of the gastrointestinal tract the test for assessing the level of immunoglobulins of the main classes in serum.

About the Authors

I. A. Novikova
Gomel State Medical University
Belarus

Irina A. Novikova, Doctor of Medical Sciences, Professor, Head of the Department

Department of Clinical Laboratory Diagnostics, Allergology and Immunology

Gomel



A. A. Ramaniva
Republican Scientific and Practical Center for Radiation Medicine and Human Ecology
Belarus

Aksana A. Ramaniva, Candidate of Medical Sciences, Immunologist

Gomel



S. A. Khoduleva
Republican Scientific and Practical Center for Radiation Medicine and Human Ecology
Belarus

Svetlana A. Khoduleva, Candidate of Medical Sciences, Associate Professor

Department of Internal Medicine № 1 with a course of Endocrinology

Gomel



N. G. Kadochkina
Republican Scientific and Practical Center for Radiation Medicine and Human Ecology
Belarus

Natalia G. Kadochkina, Candidate of Medical Sciences, General Practitioner

Department of Allergology and Immunopathology

Gomel



S. S. Prokopovich
Gomel State Medical University
Belarus

Svetlana S. Prokopovich, Assistant Lecturer

Department of Clinical Laboratory Diagnostics, Allergology and Immunology

Gomel



References

1. Cunningham-Rundles C. Common variable immune deficiency: Dissection of the variable. Immunol Rev. 2019 Jan;287(1):145-161. doi: 10.1111/imr.12728

2. O’Farrill-Romanillos PM, Herrera-Sánchez DA, Hernández-Fernández C, López-Rocha EG. Inmunodeficiencia común variable en adultos [Common immunodeficiency variable in adults]. Rev Alerg Mex. 2017 Oct-Dec;64(4):452-462. Spanish. doi: 10.29262/ram.v64i4.323

3. Tam JS, Routes JM. Common variable immunodeficiency. Am J Rhinol Allergy. 2013 Jul-Aug;27(4):260-265. doi: 10.2500/ajra.2013.27.3899

4. Saikia B, Gupta S. Common Variable Immunodeficiency. Indian J Pediatr. 2016 Apr;83(4):338-344. doi: 10.1007/s12098-016-2038-x

5. Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood. 2012 Feb 16;119(7):1650-1657. doi: 10.1182/blood-2011-09-377945

6. Ameratunga R. Assessing Disease Severity in Common Variable Immunodeficiency Disorders (CVID) and CVID-Like Disorders. Front Immunol. 2018 Sep 28;9:2130. doi: 10.3389/fimmu.2018.02130

7. Sharma M, Dhaliwal M, Tyagi R, Goyal T, Sharma S, Rawat A. Microbiome and Its Dysbiosis in Inborn Errors of Immunity. Pathogens. 2023 Mar 27;12(4):518. doi: 10.3390/pathogens12040518

8. Pellicciotta M, Rigoni R, Falcone EL, Holland SM, Villa A, Cassani B. The microbiome and immunodeficiencies: Lessons from rare diseases. J Autoimmun. 2019 Mar;98:132-148. doi: 10.1016/j.jaut.2019.01.008

9. Berbers RM, Nierkens S, van Laar JM, Bogaert D, Leavis HL. Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences. Trends Immunol. 2017 Mar;38(3):206-216. doi: 10.1016/j.it.2016.11.008

10. Chawla S, Barman P, Tyagi R, Jindal AK, Sharma S, Rawat A, Singh S. Autoimmune Cytopenias in Common Variable Immunodeficiency Are a Diagnostic and Therapeutic Conundrum: An Update. Front Immunol. 2022 Jun 20;13:869466. doi: 10.3389/fimmu.2022.869466

11. Knight AK, Radigan L, Marron T, Langs A, Zhang L, Cunningham-Rundles C. High serum levels of BAFF, APRIL, and TACI in common variable immunodeficiency. Clin Immunol. 2007 Aug;124(2):182-189. doi: 10.1016/j.clim.2007.04.012


Review

For citations:


Novikova I.A., Ramaniva A.A., Khoduleva S.A., Kadochkina N.G., Prokopovich S.S. Crohn’s disease as a debut of common variable immunodeficiency. Health and Ecology Issues. 2024;21(1):123-128. (In Russ.) https://doi.org/10.51523/2708-6011.2024-21-1-15

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)