Physiological effects of fatty acid amides in experimental peripheral neuropathy with pharmacological blockade of GPR55 receptors
https://doi.org/10.51523/2708-6011.2023-20-3-13
Abstract
Objective. To study the effect of fatty acid amides during pharmacologic blockade of GPR55 receptors on nociceptive sensitivity and gait patterns in rats in normal and experimental peripheral neuropathy.
Materials and methods. The study was carried out on male Wister rats (n=125), divided into 18 groups. The role of fatty acid amides in blockade of GPR55 receptors by administration of the antagonist O-1918 on nociceptive responses and gait parameters in healthy rats and in animals after the formation of neuropathy (NP) was studied.
Results. It was found that administration of O-1918 to healthy rats and rats with neuropathy at a dose of 1 mg/kg resulted in a statistically significant decrease in the values of nociceptive reactions and gait parameters. In healthy rats and animals after ligation of the sciatic nerve against the background of blockade of GPR55 receptors PGlyA had a pronounced antinociceptive effect, which was confirmed by a significant increase in the values of nociceptive sensitivity, as well as normalization of gait.
Conclusion. The analgesic effect after administration of PEA and SEA is probably the result of the interaction of the above FAAs with membrane orphan receptors. At the same time, the antinociceptive effect of PGlyA probably results from the activation of receptors belonging to another class, presumably vanilloid receptors of the first type.
About the Authors
A. S. Daronkina
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Anastasya S. Daronkina, Postgraduate Student, Junior Researcher at the Laboratory of Biological Modeling
Minsk
I. P. Zhavaranak
Institute of Physiology of the National Academy of Sciences of Belarus
Belarus
Belarus
Iryna P. Zhavaranak, Candidate of Biological Sciences, Head of the Laboratory of Biological Modeling
Minsk
V. G. Bogdan
Department of Medical Sciences of the National Academy of Sciences of Belarus
Belarus
Belarus
Vasily G. Bogdan, Doctor of Medical Sciences, Professor, Academician-Secretary
Minsk
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Review
For citations:
Daronkina A.S., Zhavaranak I.P., Bogdan V.G. Physiological effects of fatty acid amides in experimental peripheral neuropathy with pharmacological blockade of GPR55 receptors. Health and Ecology Issues. 2023;20(3):100-106. (In Russ.) https://doi.org/10.51523/2708-6011.2023-20-3-13
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