Polymorphic variants of the beta 2-adrenoreceptor gene (adrb2) in healthy Caucasians of the Gomel region
https://doi.org/10.51523/2708-6011.2023-20-3-10
Abstract
Objective. To study the frequency of polymorphic loci rs1042713 and rs1042714 of the β2-adrenoreceptor gene in healthy Caucasians of the Gomel region.
Materials and methods. A one-step study of 143 healthy volunteers living in Gomel region was conducted. This group included 86 (60,14%) men and 57 (39,86%) women. The average age was 36.0±10.20 years. Two single nucleotide polymorphisms (SNPs) rs1042713 and rs1042714 were genotyped in blood samples of patients by polymerase chain reaction (PCR).
Results. Among the genotypes of the rs1042713 polymorphic locus, the most common was the AG genotype (45.4%). The GG (44.1%) and AA (10.5%) genotypes were less common. The rs1042714 polymorphic locus was characterized by a more frequent presence of the CG genotype (48.9%). The CC (25.9%) and GG (25.2%) genotypes were detected less frequently. Among the alleles of polymorphic locus rs1042713, allele G was the most common (66.8%). Of the alleles of the polymorphic locus rs1042714, the C allele was more frequent (50.4%). The ADRB2 gene was more frequently represented by the AG/CG and GG/CG haplotypes (32.9% and 39.9%, respectively). AA/GG, AG/GG, and GG/ GG haplotypes were not detected among the volunteers examined.
Conclusion. AG and CG genotypes, haplotypes AG/CG and GG/CG for the polymorphic locus rs1042713 and rs1042714, respectively, were more common among Caucasians living in the Gomel region. The G allele for the polymorphic locus rs1042713 and the C allele for rs1042714 turned out to be the most common among the alleles.
About the Author
A. V. Sennikava
Gomel State Medical University
Belarus
Belarus
Alina V. Sennikava, Senior lecturer of the Department of General and Clinical Pharmacology
Gomel
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Review
For citations:
Sennikava A.V. Polymorphic variants of the beta 2-adrenoreceptor gene (adrb2) in healthy Caucasians of the Gomel region. Health and Ecology Issues. 2023;20(3):77-83. (In Russ.) https://doi.org/10.51523/2708-6011.2023-20-3-10
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