Polymorphic variants of the beta 2-adrenoreceptor gene (adrb2) in healthy Caucasians of the Gomel region
https://doi.org/10.51523/2708-6011.2023-20-3-10
Abstract
Objective. To study the frequency of polymorphic loci rs1042713 and rs1042714 of the β2-adrenoreceptor gene in healthy Caucasians of the Gomel region.
Materials and methods. A one-step study of 143 healthy volunteers living in Gomel region was conducted. This group included 86 (60,14%) men and 57 (39,86%) women. The average age was 36.0±10.20 years. Two single nucleotide polymorphisms (SNPs) rs1042713 and rs1042714 were genotyped in blood samples of patients by polymerase chain reaction (PCR).
Results. Among the genotypes of the rs1042713 polymorphic locus, the most common was the AG genotype (45.4%). The GG (44.1%) and AA (10.5%) genotypes were less common. The rs1042714 polymorphic locus was characterized by a more frequent presence of the CG genotype (48.9%). The CC (25.9%) and GG (25.2%) genotypes were detected less frequently. Among the alleles of polymorphic locus rs1042713, allele G was the most common (66.8%). Of the alleles of the polymorphic locus rs1042714, the C allele was more frequent (50.4%). The ADRB2 gene was more frequently represented by the AG/CG and GG/CG haplotypes (32.9% and 39.9%, respectively). AA/GG, AG/GG, and GG/ GG haplotypes were not detected among the volunteers examined.
Conclusion. AG and CG genotypes, haplotypes AG/CG and GG/CG for the polymorphic locus rs1042713 and rs1042714, respectively, were more common among Caucasians living in the Gomel region. The G allele for the polymorphic locus rs1042713 and the C allele for rs1042714 turned out to be the most common among the alleles.
About the Author
A. V. Sennikava
Gomel State Medical University
Belarus
Belarus
Alina V. Sennikava, Senior lecturer of the Department of General and Clinical Pharmacology
Gomel
References
1. Clinical pharmacogenetics and practical public health: integration perspectives, 2006. [Electronic resource]. Global website Scientific electronic library “CyberLeninka”. [date of access 2023 April 03]. Available from: https://cyberleninka.ru/article/n/klinicheskaya-farmakogenetika-i-prakticheskie-zdravoohranenie-perspekgivy-integratsii. (in Russ.).
2. Dedov II Personalized Medicine. Annals of the Russian academy of medical sciences. 2019;74(1):61-70. ( In Russ.).
3. Dolgopolov IS, Rykov MJ. Evolution of personalized medicine: a review of the literature. Research and practice in medicine. 2022;9(3):117-128. (In Russ.).
4. Khokhlov AL, Sychev DA. The concept of patient-centeredness in medicine and pharmacy. Patient-centered medicine and pharmacy. 2023;1(1):1-4. (In Russ.).
5. Beta-adrenergic receptor polymorphisms: A basis for pharmacogenetics, 2013. [Electronic resource]. Global website of the WJCD. [date of access 2023 April 07]. Available from: https:// www.scirp.org/pdf/WJCD_2013082616484370.pdf
6. Savelyeva ON, Karunas AS, Fedorova Yu, Husnutdinova EK. The role of polymorphic variants of the B2-adrenergic receptor gene (ADRB2) in the development and course of bronchial asthma. Medical Bulletin of Bashkortostan. 2018;5(77):69-73. (In Russ.).
7. Vasilevsky IV. Pharmacogenomics and pediatric allergology: the view of a clinical pharmacologist. In: Sat. scientific. Art. of the XIV International Scientific Congress Rational pharmacotherapy; 2019 october 17-19; St. Petersburg. St. Petersburg: SPb- SEU; 2019. p. 23-26. [date of acess 2023 April 12]. Available from: https://www.bsmu.by/files/3886a564f3de54b36071861a11f06fbc. (In Russ.).
8. rs1042713. [Electronic resource]. Global website of the National center for Biotechnology information. [date of acess 2023 April 14]. Available from: https://www.ncbi.nlm.nih.gov/snp/rs1042713
9. rs1042714. [Electronic resource]. Global website of the National center for Biotechnology information. [date of acess 2023 April 14]. Available from: https://www.ncbi.nlm.nih.gov/snp/rs1042714
10. Fedorova YuYu, Karunas RR, Murzina LA, Muhtarova LA, Ramazanova NN, Gimalova GF, et al. Investigation of the association of polymorphic variants of the ß2-adrenergic receptor gene with bronchial asthma in Russians. Practical Medicine. 2013;5(74):116-120. (In Russ.).
11. Kakhovskaya VV, Kovshun AV, Moiseenko IO, Dudchenko IO, Pristupa LN. Arg16gly polymorphism in the β2-adrenoceptor gene in patients with bronchial asthma. Wiad Lek. 2021;74(5):1200-1203. (In Russ.).
12. Sokova EA, Kukes VG. Pharmacogenetic testing by the Arg-16Gly polymorphic marker of the ADRB2 gene and the C3435T polymorphic marker of the MDR1 gene in Russian pregnant women with chronic arterial hypertension. Biomedicine. 2014; 1(4):89-98. [date of acess 2023 April 20]. Available from: https:// journal.scbmt.ru/jour/article/view/536?locale=ru_RU (In Russ.).
Review
For citations:
Sennikava A.V. Polymorphic variants of the beta 2-adrenoreceptor gene (adrb2) in healthy Caucasians of the Gomel region. Health and Ecology Issues. 2023;20(3):77-83. (In Russ.) https://doi.org/10.51523/2708-6011.2023-20-3-10
Views: 416
Email this article 