Cytokine and hormone status of women of reproductive age with pulmonary tuberculosis
https://doi.org/10.51523/2708-6011.2023-20-1-03
Abstract
Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum of women of reproductive age with pulmonary tuberculosis (TB).
Materials and methods. We studied the serum levels of γ-interferon, tumor necrosis factor α, cortisol, prolactin, estradiol, progesterone, testosterone in women 18-45 years old with newly diagnosed pulmonary TB (n = 47) compared with the same indices in women without TB and with no previous TB (n = 35).
Results. Women with pulmonary TB had higher levels of cortisol (cutoff point, 196.1 nmol/L, AUC 0.75, Se 85.1 %, Sp 70.6 %) and prolactin (cutoff point, 486, 1 mEU/L, AUC 0.69, Se 59.6%, Sp 73.5%) and lower serum progesterone levels (cutoff point 3.9 nmol/L, AUC 0.71, Se 73.9%, Sp 64.7%) than women without TB. The study of the levels of γ-interferon and TNF-α showed less diagnostic significance of the parameters, and there was a slight increase in the levels of both cytokines in women with pulmonary TB.
Conclusion. Changes in cytokine-hormone status in women with TB can both reflect mechanisms of anti-infective defense and be a consequence of the development of the disease.
About the Author
S. V. Goponiako
Gomel State Medical University
Belarus
Belarus
Svetlana V. Goponiako, Senior Lecturer, Phthysiopulmonology department with course of the Faculty of Professional Development and Retraining
Gomel
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Review
For citations:
Goponiako S.V. Cytokine and hormone status of women of reproductive age with pulmonary tuberculosis. Health and Ecology Issues. 2023;20(1):26-31. (In Russ.) https://doi.org/10.51523/2708-6011.2023-20-1-03
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