Clinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitus
https://doi.org/10.51523/2708-6011.2022-19-4-07
Abstract
Objective. To evaluate the role of the T(-344)C polymorphism of CYP11B2 gene in the development of cardiorenal syndrome (CRS) in diabetes mellitus (DM).
Materials and methods. 270 patients with type 1 and type 2 diabetes aged over 25 years were examined. All patients underwent molecular genetic analysis using deoxyribonucleic acid isolated from whole venous blood.
Results. The TT genotype was associated with the risk of developing CRS manifestations such as left ventricular hypertrophy (odds ratio (OR) 2.64; 95% CI (0.93–4.19), chronic heart failure (OR 4.26; 95% CI (2.26 - 8.06), subclinical atherosclerosis (OR 4.04; 95% CI (1.89 - 8.58), chronic kidney disease (CKD) (OR 10.77; 95% CI (3.56 - 32.61), and the CT genotype (OR 3.28; 95% CI (1.02 – 10.59) with CKD risk..
Conclusion. There are pathogenetic associations between renin-angiotensin-aldosterone system, cardiovascular complications and a decrease of renal function. Further research is needed for a deep understanding of the complex pathogenetic mechanisms of the development and progression of cardiovascular and renal pathology.
Supporting agencies: This study was supported by the Belarusian Foundation for Basic Research (BFBR) (research project No. М17РМ-113) and Russian Foundation for Basic Research (RFBR) (research project No.17-54-04080)
About the Authors
V. N. Vasilkova
Gomel State Medical University
Belarus
Belarus
Volha N. Vasilkova, Candidate of Medical Sciences,
Associate Professor of the Department of Internal Diseases №1 with a course of Endocrinology
Gomel
I. Yu. Pchelin
St. Petersburg State University
Russian Federation
Russian Federation
Ivan Yu. Pchelin, Candidate of Medical Sciences, Associate Professor performing clinical work at the Department of Faculty Therapy
St. Petersburg
Ya. A. Borovets
Gomel State Medical University
Belarus
Belarus
Yana A. Borovets, Assistant of the Department of Internal Diseases №1 with a course of Endocrinology
Gomel
I. A. Vasukhina
Republican Research Center for Radiation Medicine and Human Ecology
Belarus
Belarus
Irina A. Vasukhina, Endocrinologist
Gomel
T. V. Mokhort
Belarusian State Medical University
Belarus
Belarus
Tatsiana V. Mokhort, Doctor of Medical Sciences,
Professor, Head of the Department of Endocrinology
Minsk
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Review
For citations:
Vasilkova V.N., Pchelin I.Yu., Borovets Ya.A., Vasukhina I.A., Mokhort T.V. Clinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitus. Health and Ecology Issues. 2022;19(4):48-55. (In Russ.) https://doi.org/10.51523/2708-6011.2022-19-4-07
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