Peripheral T-Cell lymphoma with progressive multifocal skin involvement
I. V. Mikhaylov,
V. Y. Latysheva,
S. L. Achinovich,
Y. V. Silivonets,
N. L. Ksenzov,
S. S. Pulkina,
I. A. Kustikova https://doi.org/10.51523/2708-6011.2022-19-3-16
Abstract
A clinical case of peripheral T-cell lymphoma with progressive multifocal skin involvement is described, illustrating the complexity of differential diagnosis and the aggressiveness of the clinical course of this pathology. In a 49-year-old patient, the disease began with the appearance of pink plaques up to 2.0 cm in diameter on the skin of the right breast. Gradually, new lesions appeared on the skin, which were subjected to biopsy. With repeated histological, including immunohistochemical, studies, controversial results were obtained. The final diagnosis was confirmed only on the basis of a comprehensive assessment of morphological data and the presence of extradermal tumor foci. The patient underwent 16 cycles of chemotherapy using roncoleukin immunotherapy and targeted therapy with rituximab, without a pronounced clinical effect. The patient died due to the progression of the tumor process.
About the Authors
I. V. Mikhaylov
Gomel state medical University
Belarus
Belarus
Igor V. Mikhailov, PhD, head of department of oncology
Gomel
V. Y. Latysheva
Gomel state medical University
Belarus
Belarus
Valentina Ya. Latysheva, PhD, Doctor of Sciences, Professor, Professor of department of Neurology
Gomel
S. L. Achinovich
Gomel regional clinical Oncology center
Belarus
Belarus
Sergey L. Achinovich, PhD, head of the pathology department
Gomel
Y. V. Silivonets
Gomel regional clinical Oncology center
Belarus
Belarus
Yuri V. Silivonets, Deputy Chief Physician for the medical part
Gomel
N. L. Ksenzov
Gomel City Clinical Hospital No. 4
Belarus
Belarus
Nikolay L. Ksenzov, Head of the Palliative Care Department
Gomel
S. S. Pulkina
Gomel regional clinical Oncology center
Belarus
Belarus
Svetlana S. Pulkina, chemotherapist of the Chemotherapy Department
Gomel
I. A. Kustikova
Gomel regional clinical Oncology center
Belarus
Belarus
Irina A. Kustikova, anesthesiologist-resuscitator of the Intensive Care Unit
Gomel
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Review
For citations:
Mikhaylov I.V., Latysheva V.Y., Achinovich S.L., Silivonets Y.V., Ksenzov N.L., Pulkina S.S., Kustikova I.A. Peripheral T-Cell lymphoma with progressive multifocal skin involvement. Health and Ecology Issues. 2022;19(3):111-119. (In Russ.) https://doi.org/10.51523/2708-6011.2022-19-3-16
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