Extragonadal mediastinal germ cell tumor
https://doi.org/10.51523/2708-6011.2021-18-3-18
Abstract
Extragonadal germ cell tumors (GCTs) are neoplasms that develop from germ cells and have a similar histopathological structure with the gonadal forms of GCTs, but are located outside the gonads. GCTs are the most common malignant neoplasms in men aged 15–35. From 1 to 5 % of malignant GCTs are of the extragonadal origin.
The work describes a clinical case of extragonadal mediastinal germ cell tumor, which was diagnosed at the stage of the histological examination of the surgical material.
About the Authors
G. V. Tishchenko
Gomel State Medical University
Belarus
Belarus
Grigorii V. Tishchenko, PhD (Med), Assistant Lecturer at the Department of Pathological Anatomy
Gomel
A. I. Shalyga
Gomel State Medical University
Belarus
Belarus
Alina I. Shalyga, Assistant Lecturer at the Department of Propedeutics of Internal Diseases
Gomel
I. A. Tsishchanka
Gomel Regional Clinical Pathology Bureau
Belarus
Belarus
Iryna A. Tsishchanka, pathologist
Gomel
References
1. Imyanitov EN. Epidemiology and biology of germ cell tumors. Prakticheskaya onkologiya. 2006;7(1):1-5. (in Russ.).
2. De Felici M, Klinger FG, Campolo F, Balistreri CR, Barchi M, Dolci S. To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm. International Journal of Molecular Sciences. 2021 Jan;22(11):5982. DOI: https://doi.org/10.3390/ijms22115982
3. Schmoll HJ. Extragonadal germ cell tumors. Annals of Oncology. 2002 Oct 1;13(4):265-272. DOI: https://doi.org/10.1093/annonc/mdf669
4. Ronchi A, Cozzolino I, Montella M, Panarese I, Zito Marino F, Rossetti S, Chieff P, Accardo M, Facchini G, Franco R. Extragonadal germ cell tumors: not just a matter of location. A review about clinical, molecular and pathological features. Cancer medicine. 2019 Nov;8(16):6832-6840. DOI: https://doi.org/10.1002/cam4.2195
5. Klimenko VN. Extragonadal germ cell tumors. Prakticheskaya onkologiya. 2006;7(1):63-68. (in Russ.).
6. Teilum G. Classifcation of endodermal sinus tumour (mesoblastoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathologica Microbiologica Scandinavica. 1965 Sep;64(4):407-429. DOI: https://doi.org/10.1111/apm.1965.64.4.407
7. Albany C, Einhorn LH. Extragonadal germ cell tumors: clinical presentation and management. Current opinion in oncology. 2013 May 1;25(3):261-265. DOI: https://doi.org/10.1097/CCO.0b013e32835f085d
8. Bosl GJ, Ilson DH, Rodriguez E, Motzer RJ, Reuter VE, Chaganti RS. Clinical relevance of the i(12p) marker chromosome in germ cell tumors. J Natl Cancer Inst. 1994 Mar 2;86(5):349-355. DOI: https://doi.org/10.1093/jnci/86.5.349
9. Chaganti RS, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Research. 2000 Mar 15;60(6):1475-1482.
10. Rosado-de-Christenson ML, Templeton PA, Moran CA. From the archives of the AFIP. Mediastinal germ cell tumors: radiologic and pathologic correlation. RadioGraphics. 1992 Sep;12(5):1013-1030. DOI: https://doi.org/10.1148/radiographics.12.5.1326777
Review
For citations:
Tishchenko G.V., Shalyga A.I., Tsishchanka I.A. Extragonadal mediastinal germ cell tumor. Health and Ecology Issues. 2021;18(3):144-151. (In Russ.) https://doi.org/10.51523/2708-6011.2021-18-3-18
Views: 359
Email this article 