Analytical assessment of hospital management of patients with COVID-19
https://doi.org/10.51523/2708-6011.2021-18-3-6
Abstract
Objective. To conduct an analytical assessment of the dynamics of the state of patients with COVID-19 in the conditions of a clinical healthcare organization taking into account comorbid diseases.
Materials and methods. 96 in-patients` medical records kept in the state healthcare institution “Gomel City Clinical Hospital No.3” have been retrospectively analyzed.
Results. The median age for women having undergone hospital treatment for pneumonia associated with COVID-19 was 58 years [45; 66], for men — 58 years [39; 64]. All the patients underwent a clinical examination according to temporary protocols. The most frequent comorbid diseases in the patients with COVID-19 were: arterial hypertension, ischemic heart disease, non-alcoholic liver disease, diabetes mellitus, chronic pyelonephritis, obesity. Polymorbidity was revealed in 49 % of the patients. Most patients had moderately severe pneumonia associated with COVID-19 (75 % of all the surveyed patients). In the patients with a mild course of pneumonia associated with COVID-19, the neutrophil-to-lymphocyte ratioin the peripheral blood was 2.1, whereas in the patients with a severe course — 8.82, which correlated with traditional prognostic indicators — the levels of C-reactive protein, d-dimers, lactate dehydrogenase.
Conclusion. The neutrophil-to-lymphocyte ratio in the peripheral blood is a simple and affordable method of COVID-19 course prediction in comorbid patients.
About the Authors
O. L. Nikiforova
Gomel State Medical University
Belarus
Belarus
Olga L. Nikiforova, Assistant Lecturer at the Department of Polyclinic Therapy and General Medical Practice
Gomel
N. V. Galinovskaya
Gomel State Medical University
Belarus
Belarus
Natalya V. Galinovskaya, DMedSc, Professor, Dean of the Faculty of Professional Development and Retraining
Gomel
P. N. Kovalchuk
Gomel State Medical University
Belarus
Belarus
Peter N. Kovalchuk, PhD (Med), Associate Professor, Associate Professor at the Department of Polyclinic Therapy and General Medical Practice
Gomel
References
1. Basdirev ED. Coronovirus infection is an actual problem of the XXI century. Complex problems of cardiovascular diseases. 2020;9(2):6-16. (In Russ.). DOI: https://doi.org/10.17802 / 2306-1278-2020-9-2-6-16
2. Popovich YG, Rakhimova RJ, Akhmetzhanov DO. COVID-19 is a new XXI century infection. Science and healthcare. 2020;4(22):15-23. (In Russ.). DOI: https://doi.org/10.34689 / SH.2020.22.4.002
3. COVID-19 Map – Johns Hopkins Coronavirus Resource Center [date of access 2021 June 18]. Available from: https://coronavirus.jhu.edu/map.html
4. Nile SH, Nile A, Qiu J, Li L, Jia X, Kai G, COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine Growth Factor Rev. 2020;53:66-70. DOI: https://doi.org/10.1016/j.cytogfr.2020.05.002
5. Sun Y, Dong Y, Wang L, Xie H, Li B, et al. Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience. J Autoimmun. 2020;112:102473. DOI: https://doi.org/10.1016/j.jaut.2020.102473
6. Ripa M, Galli L, Poli A, Oltolini C, Spagnuolo V, et al. Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors. Clin Microbiol Infect. 2021;27(3):451-457. DOI: https://doi.org/10.1016/j.cmi.2020.10.021
7. Gallo Marin B, Aghagoli G, Lavine K, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol. 2021;31(1):1-10. DOI: https://doi.org/10.1002/rmv.2146
8. Rostami M, Mansouritorghabeh H, D-dimer level in COVID-19 infection: a systematic review. Expert Rev Hematol. 2020;13(11):1265-1275. DOI: https://doi.org/10.1080/17474086.2020.1831383
9. Kovalchuk LS. Long QT syndrome and its role in THE development of severe heart rhythm disturbances and sudden death. Health and Ecology Issues. 2016;(3):13-19. [date of access 2021 June 10]. Available from: https://journal.gsmu.by/jour/article/view/1705 (In Russ.).
10. Leonova MV. Сardiotoxicity of chloroquine and hydroxychloroquine in the treatment of COVID-19 infection. Consilium Medicum. 2020;22(10):15-21. (In Russ.). DOI: https://doi.org/10.26442/20751753.2020.10.200270
11. Alkhatip AAAMM, Kamel MG, Hamza MK, Farag EM, Yassin HM, et al. The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis. Expert Rev Mol Diagn. 2021;25;505-514. DOI: https://doi.org/10.1080/14737159.2021.1915773
12. Li X, Liu C, Mao Z, Xiao M, Wang L, et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care. 2020;24(1):647. DOI: https://doi.org/10.1186/s13054-020-03374-8
13. Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, Luo M, Chen L, Zhao Y. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J Infect. 2020;81(1):e6-e12. DOI: https://doi.org/10.1016/j.jinf.2020.04.002
14. Shang W, Dong J, Ren Y, Tian M, Li W, Hu J, Li Y. The value of clinical parameters in predicting the severity of COVID-19. J Med Virol. 2020;92(10):2188-2192. DOI: https://doi.org/10.1002/jmv.26031
15. Han MA, Kim JH, Diagnostic X-Ray Exposure and Thyroid Cancer Risk: Systematic Review and Meta-Analysis. Thyroid. 2018;28(2):220-228. DOI: https://doi.org/10.1089/thy.2017.0159
Review
For citations:
Nikiforova O.L., Galinovskaya N.V., Kovalchuk P.N. Analytical assessment of hospital management of patients with COVID-19. Health and Ecology Issues. 2021;18(3):47-56. (In Russ.) https://doi.org/10.51523/2708-6011.2021-18-3-6
Views:
422
Email this article 