CELL THERAPY OF EXPERIMENTAL LIVER CIRRHOSIS IN RABBITS
https://doi.org/10.51523/2708-6011.2017-14-1-12
Abstract
Objective: to evaluate the efficiency of mesenchymal stem cell transplantation in the treatment of experimental liver cirrhosis in rabbits. Material and methods. White Californian rabbits (15 individuals) weighing 2.5-3 kg and aged 7-8 months were used as objects for modeling of toxic liver injury. Modeling of acute and chronic liver injuries was performed by subcutaneous injection of 50 % solution of carbon tetrachloride (CCl4) at a dose of 1 ml/kg twice a week. Autologous mesenchymal stem cells (MSCs) were used as therapeutic agents. The rabbits were injected MSC suspension intraportally under mask anesthesia. Results. Subcutaneous injection of carbon tetrachloride for 5 months leads to the development of toxic liver injury in rabbits. We noted an improvement of the histological picture of the injured liver a month after the injection of autologous MSCs in the rabbits with liver cirrhosis in comparison with the rabbits of the control group which were not injected MSCs. Conclusion. Translantation of autologous MSCs has a positive therapeutic effect in the treatment of experimental liver cirrhosis in rabbits.
About the Authors
B. B. Osipov
Gomel State Medical University
Belarus
Belarus
A. N. Lyzikov
Gomel State Medical University
Belarus
Belarus
A. G. Skuratov
Gomel State Medical University
Belarus
Belarus
D. R. Petreniov
Gomel State Medical University
Belarus
Belarus
A. A. Prisentsov
Gomel State Medical University
Belarus
Belarus
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Review
For citations:
Osipov B.B., Lyzikov A.N., Skuratov A.G., Petreniov D.R., Prisentsov A.A. CELL THERAPY OF EXPERIMENTAL LIVER CIRRHOSIS IN RABBITS. Health and Ecology Issues. 2017;(1):57-62. (In Russ.) https://doi.org/10.51523/2708-6011.2017-14-1-12
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