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INTERLEUKIN-6 AS AN INDICATOR OF SEVERITY OF LIVER CIRRHOSIS AND PORTAL HYPERTENSION

https://doi.org/10.51523/2708-6011.2016-13-4-24

Abstract

Objective: to study the level of interleukin-6 in the blood of patients with liver cirrhosis and to identify the diagnostic significance of this parameter. Material and methods. We have done the research among patients with chronic liver diseases (cirrhosis, chronic hepatitis, non-alcoholic fatty liver disease) and have determined the IL-6 level in the blood plasma in the patients and in healthy people of the control group. Conclusion. We have revealed a statistically significant increase of the interleukin-6 level in the blood plasma of the patients with liver cirrhosis compared to the similar parameter in the healthy people of the comparison group. The degree of the increased IL-6 level was directly proportional to the severity of the pathological process. The value of the concentration of interleukin-6 in the blood can be used as an additional criterion for evaluation of severity of liver cirrhosis and portal hypertension.

About the Authors

A. G. Skuratov
Gomel State Medical University
Belarus


A. N. Lyzikov
Gomel State Medical University
Belarus


E. V. Voropaev
Gomel State Medical University
Belarus


O. V. Osipkina
Gomel State Medical University
Belarus


References

1. Ивашкин, В. Т. Осложнения портальной гипертензии при циррозе печени / В. Т. Ивашкин // Российский физиологический журнал. - 2009. - № 10. - С. 74-76.

2. Симбирцев, А. С. Цитокины: классификация и биологические функции / А. С. Симбирцев // Цитокины и воспаление. - 2004. - Т. 3, № 2. - С. 16-22.

3. Iwakir, Y. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule / Y. I. Wakiri, R. J. Groszmann // Hepatology. - 2006. - Vol. 43, Suppl. 1. - Р. 122-130.

4. Chen, T. A. Effect of intravenous albumin on endotoxin removal, cytokines, and nitric oxide production in patients with cirrhosis and spontaneous bacterial peritonitis / T. A. Chen, T. Y. Csao, T. A. Chen // Scand. J. Gastroenterol. - 2009. - Vol. 44, № 5. - Р. 619-625.

5. Кукош, М. В. Современные серологические маркеры острого панкреатита / М. В. Кукош, М. С. Петров, Н. В. Емельянов // Нижегородский медицинский журнал. - 2003. - № 3-4. - С. 25-27.

6. La Villa, G. Hemodynamic alterations in liver cirrhosis / G. La Villa, P. Gentilini // Mol. AspectsMed. - 2008. - Vol. 29. - Р. 113-119.

7. Интерлейкин - 6 и оксид азота в патогенезе портальной гипертензии и декомпенсации цирроза печени / Г. К. Мироджанов [и др.] // Клиническая медицина. - 2012. - № 1. - С. 47-53.

8. Köksal, A. S. Clinical features, serum interleukin-6, and interferon-gamma levels of 34 Turkish patients with hepatoportal sclerosis / A. S. Köksal, S. Köklű, M. Ibic // Dig. Dis. Sci. - 2007. - Vol. 52, № 12. - Р. 3494-3497.


Review

For citations:


Skuratov A.G., Lyzikov A.N., Voropaev E.V., Osipkina O.V. INTERLEUKIN-6 AS AN INDICATOR OF SEVERITY OF LIVER CIRRHOSIS AND PORTAL HYPERTENSION. Health and Ecology Issues. 2016;(4):110-114. (In Russ.) https://doi.org/10.51523/2708-6011.2016-13-4-24

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)