THE MORPHOLOGICAL FEATURES OF THE LIVER WOUND SURFACE AFTER ITS CLOSURE WITH VARIOUS MATERIALS IN EXPERIMENT

Abstract

Objective: to study the morphological changes occurring after closure of the liver wound with omentum and fragment of the synthetic material fluoroplastis-4 in experiment. Material and methods. Modeling of the marginal resection of the liver was performed on white rats in experiment. Depending on the material used for the plastic closure of the wound surface, the experimental animals were divided into two groups (comparative and experimental): in the 1st group, a strand of omentum on the vascular pedicle was used, in the 2nd - a fragment of fluoroplastic-4. After the rats had been excluded from the experiment, the macroscopic changes in the abdominal cavity were evaluated and sampling from the surgery zone for the manufacture of histological preparations and study by means of light microscopy was done. Morphometric studies were carried out with the statistical processing of the received data. Results. Using greater omentum in late terms after the operation we detect adhesions within the area of the resection, presence of newly formed capsules of the liver under the omentum and no signs of inflammation. At the microscopic level, the key feature of the use of fluoroplastic-4 is the formation of a connective tissue capsule around the material. Another characteristic feature of its use is presence of giant multinucleated cells of foreign bodies on the boundary «polymer-liver». Conclusion. The experimental study demonstrates the viability and morphological substantiation of application of synthetic polymer fluoroplastic-4 as an alternative method of closure of the liver wound surface after resection.