INDIRECT MARKERS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B AND C
https://doi.org/10.51523/2708-6011.2016-13-3-5
Abstract
Objective: to assess the value of indirect markers of liver fibrosis in patients with chronic hepatitis B (CHB) and C (CHC). Material and methods. We have examined 137 patients with CHB (n = 34) and CHC (n = 103) having known the stage of liver fibrosis based on liver biopsy or indirect methods (fibroelastography, FibroTest). 9 parameters of hemogram and biochemical blood test along with 8 indices calculated on their base were taken into account. Their prognostic values were evaluated by means of ROC analysis. Results. The higher fibrosis stage is in patients with CHB and CHC, the lower platelet, cholesterol, albumin rates are in peripheral blood and the higher RDW, MPV, ALT, AST, ALP, GGT levels are (p < 0.05). The indices of Forns, S-index, FIB-4, Virahep-C model, APRI, RDW/PLT, MPV/PLT are significantly different (p < 0.0001) in patients with minimal (F0-F1) and evident (F2-F4) fibrosis. Forns index, Virahep-C model, FIB-4, and RDW/PLT are the most significant predictors of evident liver fibrosis (F2-F4) for patients with CHB. S-index index, Forns, FIB-4, and Virahep-C model have the greatest predictive value in patients with CHC. Conclusion. The assessment of indirect markers of liver fibrosis in patients with CHB and CHC can be easily performed at any stage of the treatment, it is quite informative and can be used for selection of patients for further examination and timely antiviral therapy.
About the Authors
V. M. Mitsura
Gomel State Medical University
Belarus
Belarus
D. V. Tereshkov
Gomel Regional Infectious Clinical Hospital
Belarus
Belarus
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For citations:
Mitsura V.M., Tereshkov D.V. INDIRECT MARKERS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B AND C. Health and Ecology Issues. 2016;(3):24-29. (In Russ.) https://doi.org/10.51523/2708-6011.2016-13-3-5
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