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A CLINICAL CASE OF ACUTE ETHYLENE GLYCOL POISONING

https://doi.org/10.51523/2708-6011.2016-13-2-19

Abstract

Acute ethylene glycol poisoning is a topical medical and social problem. According to the statistics, ethylene glycol poisoning ranks second among intoxications with technical liquids. The availability of ethylene glycol and lack of public awareness about its poisonous properties is a condition for the occurrence of poisoning. The clinical picture of ethylene glycol intoxication is characterized by the development of three successive stages: the first stage - CNS depression (narcotic phase), the second stage - toxic lesions of the heart and the lungs, the third stage - toxic lesions of the liver, kidneys with the development of acute kidney failure, as well as metabolic acidosis. The article presents a case report of acute poisoning with ethylene glycol, gives the results of the diagnostic activities, the dynamics of the clinical manifestations and laboratory parameters, describes the treatment of the patient.

About the Authors

A. M. Kravchenko
Gomel State Medical University
Belarus


E. G. Malayeva
Gomel State Medical University
Belarus


I. A. Hudyakov
Gomel City Clinical Hospital No3
Belarus


E. V. Tsitko
Gomel City Clinical Hospital No3
Belarus


A. A. Dmitrienko
Gomel City Clinical Hospital No3
Belarus


A. A. Filitovich
Gomel City Clinical Hospital No3
Belarus


T. M. Kostko
Gomel City Clinical Hospital No3
Belarus


A. N. Kozlovskiy
Gomel City Clinical Hospital No3
Belarus


A. P. Mistyukevich
Gomel City Clinical Hospital No3
Belarus


A. S. Denisov
Gomel City Clinical Hospital No3
Belarus


References

1. Бережной, Р. В. Судебно-медицинская экспертиза отравлений техническими жидкостями / Р. В. Бережной. - М.: Медицина, 1977. - 208с.

2. Состояние костномозгового кроветворения и некоторых паренхиматозных органов в условиях токсического стресса при отравлении этиленгликолем / О. Н. Шашкова [и др.] // Сибирский медицинский журнал. - 2002. - Т. 32, № 3. - С. 31-32.

3. Лужников, Е. А. Клиническая токсикология / Е. А. Лужников. - М.: Медицина, 1994. - 254 с.

4. Kristen, H. Ethylene Glycol toxity / Н. Kristen // Clinical toxicology review. - 2003. - Vol. 25, № 2. - Р. 9-11.

5. Treatment of ethylene glicol poisoning / R. D. Scalley [et al.] // American Family Physician. - 2002. - № 66(5). - P. 807-813.

6. Dianyi, Yu. Agency for Toxic Substances and Disease Registry Case Studies in Environmental Medicine (CSEM) Ethylene Glycol and Propylene Glycol Toxicity/ Yu. Dianyi [et al.] // [Electronic resourse]. - 2003. - P 65. - Mode of access: http://www.atsdr.cdc. gov/csem/egpg/docs/egpg.pdf.- Date of access:01.03.2016.

7. Бонитенко, Е. Ю Сравнительная характеристика отравлений этиленгликолем и его эфирами / Е. Ю. Бонитенко // Российский биомедицинский журнал. - 2003. - Т. 4. - С. 486-490.

8. Ethylene glycol poisoning: a rare but life-threatening cause of metabolic acidosis - a single-centre experience / J. Latus [et al.] // Clinical Kidney Journal. - 2012. - № 5(2). - P. 120-123.

9. Овсиюк, Ю. А.Патоморфологические изменения во внутренних органах человека и белой крысы при отравлении этиленгликолем / Ю. А. Овсиюк А. А. Жукова Д. А. Зиновкин // Проблемы здоровья и экологии. - 2010. - № 1(23). - С. 107-109.

10. Ethylene glycol poisoning: toxicokinetic and analytical factors affecting laboratory diagnosis / A. F. Eder [et al.] // Clinical Chemistry. - 1998. - Vol. 44, № 1. - P. 168-177.

11. Buller, G. K. The Role of Hemodialysis and Fomepizole in Ethylene Glycol Intoxication/ G. K. Buller, C. B. Moskowitz, K. Eckardt // J. Nephrol. Therapeut [Electronic resourse]. - 2012. - № 10. - Mode of access: http://dx.doi.org/10.4172/2161-0959.S10-004. - Date of access:07.03.2016.

12. Ethylene glycol poisoning. Pharmacokinetics during therapy with ethanol and hemodialysis / C. D. Peterson [et al.] // New Engl. J. Med. - 1981. - Vol. 304, № 1. - P. 21-23.

13. Овсиюк, Ю. А. Анализ отравлений этиленгликолем в Гомельской области за период 1998-2004 годов / Ю. А. Овсиюк, Т. Н. Сацура // Проблемы здоровья и экологии. - 2005. - № 1(3). - С. 121-123.


Review

For citations:


Kravchenko A.M., Malayeva E.G., Hudyakov I.A., Tsitko E.V., Dmitrienko A.A., Filitovich A.A., Kostko T.M., Kozlovskiy A.N., Mistyukevich A.P., Denisov A.S. A CLINICAL CASE OF ACUTE ETHYLENE GLYCOL POISONING. Health and Ecology Issues. 2016;(2):89-95. (In Russ.) https://doi.org/10.51523/2708-6011.2016-13-2-19

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)