THE CLINICAL AND MORPHOLOGICAL ANALYSIS OF TRIPLE NEGATIVE BREAST CANCER REVEALED IN GOMEL REGION IN 2014
https://doi.org/10.51523/2708-6011.2016-13-2-11
Abstract
Objective: to study the clinical and morphological characteristics of triple negative breast cancer (TNBC) revealed in Gomel region in 2014. Material and methods . The material of the study became 85 cases of TNBC revealed in Gomel region in 2014. The clinical and morphological analysis was made on the database of the Pathoanatomical Branch of the Gomel Regional Clinical Oncological Clinic. Results . In the year of 2014 TNBC was detected in 85 out of 412 cases of BC, which made up 20.6 %. The similar results in the same year were received in Vitebsk region - 82 out of 425 (19.3 %) and Grodno region - 77 out of 380 (20 %). The average age of the patients with TNBC was 56.0 years, which corresponded to literary data and practically did not differ from the data received in Vitebsk region - 55.8 years and Grodno region - 56.5 years. Conclusion. The results of the study of the histological degree of malignancy, prediction indicators (TNM) and parities of clinical stages have confirmed the data of the given literary sources on more adverse prognostic value of TNBC detection. The clinical and morphological characteristics of TNBC revealed in Gomel region in the year of 2014 correspond to the data of literary sources and the results received during the study in other regions of Belarus.
About the Authors
A. Yu. Krylov
Institute of Improvement of Professional Skill and Retraining of Personnel of the State Committee of Judicial Examinations of Belarus
Belarus
Belarus
Yu. V. Krylov
Vitebsk Regional Clinical Pathoanatomical Bureau
Belarus
Belarus
S. L. Achinovich
Gomel Regional Clinical Oncological Clinic
Belarus
Belarus
L. A. Martemyanova
Gomel State Medical University
Belarus
Belarus
S. Y. Turchenko
Gomel State Medical University
Belarus
Belarus
References
1. Клинические рекомендации. Онкология / В. И. Чиссов [и др.]. ; под ред. В. И. Чиссова. - 2-е изд., испр. и доп. - М.: ГЭОТАР-Медиа, 2009. - 928 с.
2. Состояние онкологической помощи населению России в 2011 году / В. И. Чиссов [и др.]; под ред. В. И. Чиссова. - М.: ФГБУ «МНИОИ им. П. А. Герцена Минздравсоцразвития РФ», 2012. - 240 с.
3. Pattern of metastatic spread in triple-negative breast cancer / R. Dent [et al.] // Breast Cancer Res. Treat. - 2008. - Vol. 115, № 2. - P. 423-428.
4. Nishimura, R. Is triple negative a prognostic factor in breast cancer? / R. Nishimura, N. Arima // Breast Cancer. - 2008. - Vol. 15, № 4. - P. 303-308.
5. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype / M. C. Cheang [et al.] // Clin. Canceres. - 2008. - Vol. 14, № 5. - P. 1368-1376.
6. Clinical outcomes after a diagnosis of brain metastases in patients with estrogen and/or human epidermal growth factor receptor 2-positive versus triple-negative breast cancer / S. L. Hines [et al.] // Ann. Oncol. - 2008. - Vol. 19, № 9. - P. 1561-1565.
7. Single centre clinical of a Greek patient population with triple-negative breast cancer / D. Panousis [et al.] // Hellenic Journal of Surgery. - 2014. - Vol. 86, № 5. - P. 280-286.
8. Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single institution compilation compared with the National Cancer Institute’s Surveillance, Epidemiology, and results database / G. J. Morris [et al.] // Cancer. - 2007. - Vol. 110, № 4. - P. 876-884.
9. High prevalence of triple-negative tumors in an urban cancer center / M. J. Butler [et al.] // Cancer. - 2008. - Vol. 113, № 3. - P. 608-615.
10. Риск развития рака молочной железы после воздействия ионизирующего излучения вследствие Чернобыльской катастрофы / Е. Я. Сосновская [и др.] // Журнал «Медицинские новости». - 2006. - № 3. - С. 31-36.
11. Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basallike breast carcinomas) / E. Lerma [et al.] // Mod. Pathol. - 2007. - Vol. 20, № 11. - P. 1200-1207.
12. Identificaation of prognostic different subgroups in triple negative breast cancer by Her2-neu protein expression / Gilda Schmidt [et al.] // Arch. Gynecol Obster. - 2014. - Vol. 209. - P. 1221-1229.
13. Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive / Van Calster B. [et al.] // Breast Cancer Res. Treat. - 2009. - Vol. 113, № 1. - P. 181-187.
14. Clinical characteristics and prognosis of triple-negative breast cancer: a report of 305 cases / Z. Y. Yuan [et al.] // Ai Zheng. - 2008. - Vol. 27, № 6. - P. 561-565.
15. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer / B. G. Haffty [et al.] // J. Clin. Oncol. - 2006. - Vol. 24. - P. 5652-5657.
16. Clinicopathological features of the triple-negative tumors in Chinese breast cancer patients / W. J. Yin [et al.] // Breast Cancer Res. Treat. - 2009. - Vol. 115, № 2. - Р. 325-333.
Review
For citations:
Krylov A.Yu., Krylov Yu.V., Achinovich S.L., Martemyanova L.A., Turchenko S.Y. THE CLINICAL AND MORPHOLOGICAL ANALYSIS OF TRIPLE NEGATIVE BREAST CANCER REVEALED IN GOMEL REGION IN 2014. Health and Ecology Issues. 2016;(2):53-57. (In Russ.) https://doi.org/10.51523/2708-6011.2016-13-2-11
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