ГЕОМЕТРИЧЕСКИЕ И ФИЗИКО-МЕХАНИЧЕСКИЕ ПАРАМЕТРЫ ФИБРОБЛАСТОВ И РАКОВЫХ КЛЕТОК ЧЕЛОВЕКА ЛИНИЙ А549 и HEp-2c, ОЦЕНЕННЫЕ С ПОМОЩЬЮ АТОМНО-СИЛОВОЙ МИКРОСКОПИИ
https://doi.org/10.51523/2708-6011.2016-13-1-13
Abstract
Using an atomic force microscopy we studied the physical and mechanical parameters of cell surface layer patches (the parameters of local sliding friction force between atomic force microscope tip and cell surface and the fractal dimension of lateral force maps) and geometrical parameters of whole cells (cell contour, topography, diameter, height and others) for treated with glutaraldehyde (0,5 %) human fibroblasts and cancer epithelial cells lines A549 (lung carcinoma) and HEp-2c (larynx carcinoma). The revealed differences in the studied parameters are indicative of the difference in the cortical cytoskeleton state of the cells.
About the Authors
M. N. Starodubtseva
Gomel State Medical University
Belarus
Belarus
I. E. Starodubtsev
Gomel State Medical University
Belarus
Belarus
D. R. Petrenyov
Institute of Radiobiology NAS Belarus
Belarus
Belarus
N. I. Yegorenkov
Gomel State Medical University
Belarus
Belarus
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Review
For citations:
Starodubtseva M.N., Starodubtsev I.E., Petrenyov D.R., Yegorenkov N.I. . Health and Ecology Issues. 2016;(1):60-66. (In Russ.) https://doi.org/10.51523/2708-6011.2016-13-1-13
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