The Role of the Hepatic Tissue Remodeling Regulators MMP-9 and TIMP-1 in the Progression of Liver Cirrhosis
https://doi.org/10.51523/2708-6011.2019-16-4-18
Abstract
Objective: to study the level of the hepatic tissue remodeling regulators MMP-9 and TIMP-1 in the blood of patients with the progression of chronic diffuse liver diseases.
Material and methods. The object of the study was 80 patients with chronic diffuse liver diseases (chronic hepatitis and cirrhosis). The concentration of MMP-9 and TIMP-1 in the blood of the patients was determined by enzymelinked immunosorbent assay (ELISA).
Results: As chronic diffuse liver diseases progressed, a statistically significant decrease in the level of MMP-9 in the blood of the patients was revealed, which was reflected in the decreased intensity of the extracellular matrix resorption processes and transformation of chronic hepatitis into liver cirrhosis. The activity of TIMP-1 which suppressed the fibrolytic effects of MMP-9, was statistically significantly higher in the viral etiology of liver cirrhosis, which probably led to more rapid progression of liver fibrosis associated with the presence of hepatitis C and В viruses.
About the Authors
A. G. Skuratov
Gomel State Medical University
Belarus
Belarus
Skuratov A.G., PhD, Associate Professor of the Department of Surgical Diseases No.1 with the course of Cardiovascular Surgery of the educational institution «Gomel State Medical University».
A. N. Lyzikov
Gomel State Medical University
Belarus
Belarus
Lyzikov A.N., MD, Professor, Rector of the educational institution «Gomel State Medical University».
E. V. Voropaev
Gomel State Medical University
Belarus
Belarus
Voropaev E.V., PhD, Associate Professor, Vice-rector in charge of scientific work of the educational institution «Gomel State Medical University».
O. V. Osipkina
Gomel State Medical University
Belarus
Belarus
Osipkina O.V., Head of the Research Laboratory of the educational institution «Gomel State Medical University».
D. V. Tereshkov
Gomel State Medical University
Belarus
Belarus
Tereshkov D.V., postgraduate student at the Department of Infectious Diseases of the educational institution «Gomel State Medical University», Head of the Infectious Diseases Ward No.4 of Gomel Regional Infectious Diseases Clinical Hospital.
N. M. Golubykh
Gomel State Medical University
Belarus
Belarus
Golubykh N.M., researcher at the Research Laboratory of the educational institution «Gomel State Medical University».
M. N. Yatsuk
Gomel State Medical University
Belarus
Belarus
Yatsuk M.N., researcher at the Research Laboratory of the educational institution «Gomel State Medical University».
A. N. Kondrachuk
Gomel State Medical University
Belarus
Belarus
Kondrachuk A.N., Senior researcher at the Research Laboratory of the educational institution «Gomel State Medical University».
A. E. Kozlov
Institute of Radiobiology of the NAS of Belarus
Belarus
Belarus
Kozlov A.E., researcher of the state scientific institution «Institute of Radiobiology of the NAS of Belarus».
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Review
For citations:
Skuratov A.G., Lyzikov A.N., Voropaev E.V., Osipkina O.V., Tereshkov D.V., Golubykh N.M., Yatsuk M.N., Kondrachuk A.N., Kozlov A.E. The Role of the Hepatic Tissue Remodeling Regulators MMP-9 and TIMP-1 in the Progression of Liver Cirrhosis. Health and Ecology Issues. 2019;(4):88-94. (In Russ.) https://doi.org/10.51523/2708-6011.2019-16-4-18
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