THE CONTRIBUTION OF POLYMORPHIC VARIANTS P.P72R (TP53) AND P.V353A (HMMR) IN THE GENESIS OF SPORADIC BREAST CANCER

Aim: to study the contribution of TP53 and HMMR genes to the genesis of sporadic forms of breast cancer in patients from Belarus. Material and methods. The study included 169 patients with sporadic breast cancer, molecular genetic analysis was performed by RFLP analysis and PAGE electrophoresis. Results. The polymorphic variants p.72R ( TP53 , rs1042522) and p.V353A ( HMMR , rs299290) in patients with breast cancer from Belarus were analyzed. The frequencies of genotypes and alleles prevalence in patients with breast cancer (and in the comparison group) and compared the results with the data by ESP Cohort Populations. The relation of the results of genotyping to the clinical and morphological characteristics of the tumor was analyzed. The study revealed statistically significant differences (p = 0.029) between the frequency of the prevalence of the genotype CC ( TP53 , p.R72P) and the level of expression of the Her-2/neu in the patients with breast cancer. The genotype CT ( HMMR , p.V353A) is associated with estrogen-negative breast tumors (p = 0.016). Conclusion. The polymorphic variants p.72R ( TP53 , rs1042522) and p.V353A ( HMMR , rs299290) have no significant modifying effect on the risk of sporadic breast cancer, but at the same time, there is a link between the presence of a particular genotype and the clinical morphological characteristics of the tumor.

рак молочной железы, полиморфизм, риск развития заболевания, TP53, HMMR, эстрогеновые и прогестероновые рецепторы, Her-2/neu, молекулярный подтип опухоли, breast cancer, polymorphism, the risk of the disease development, TP53, HMMR, estrogen and progesterone receptors, Her-2/neu, molecular subtype of tumor

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