THE ROLE OF IL-8 (Т251А) GENE POLYMORPHISM IN THE PATHOGENESIS OF GASTRIC DISEASES
https://doi.org/10.51523/2708-6011.2015-12-4-5
Abstract
Objective: to assess the role of IL-8 (Т251А) gene polymorphism in the pathogenesis of gastric diseases. Materials and methods. The study included 250 patients diagnosed with chronic gastritis and 72 patients diagnosed with gastric cancer. To define IL-8 (Т251А) gene polymorphism, and detect the DNA of H. pylori and СаgA genotype, we used the method of allel-specific polymerase chain reaction (AS PCR). Results. The presence of ТА IL-8 genotype (T251A) in a patient increases twice as much the risk for gastric cancer regardless of the status of СagA infection with H. pylori positive strains (р = 0.006). Conclusion. ТА IL-8 (T251A) genotype was significantly more prevalent in gastric cancer: χ2 = 0.006; OR - 2.07; 95 % CI 1.22-3.53. The diagnostic sensitivity of detection of this genotype makes up 55.6 %, the diagnostic specificity - 62.4. The presence of reliable differences in the distribution of alleles and genotypes is indicative of the association of the polymorphic marker with the illness, in this particular case, the presence of ТА IL-8 (T251A) genotype in a patient increases twice as much the risk for the development of gastric cancer. While studying the interrelations between IL-8 (T251A) polymorphism and stomach atrophy we revealed no reliable differences (χ2 = 0.249). The differences between the activity of gastritis and IL-8 (T251A) (χ2 = 0.341) polymorphism are statistically unreliable. No interrelation between IL-8 (T251A) polymorphism and СagA+ infection with H. pylori strains in both the studied groups was found: χ2 =0.188 in the group with chronic gastritis and χ2 =0.181 in the group with gastric cancer.
Keywords
H. pylori,
генотип,
аллели,
интерлейкин-8,
рак желудка,
гастрит,
H. pylori,
genotype,
alleles,
interleukin-8,
gastric cancer,
gastritis
About the Author
A. V. Voropayeva
Republican Research Centre for Radiation Medicine and Human Ecology
Belarus
Belarus
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Review
For citations:
Voropayeva A.V. THE ROLE OF IL-8 (Т251А) GENE POLYMORPHISM IN THE PATHOGENESIS OF GASTRIC DISEASES. Health and Ecology Issues. 2015;(4):29-32. (In Russ.) https://doi.org/10.51523/2708-6011.2015-12-4-5
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