DYNAMICS OF MORPHOLOGICAL CHANGES IN PLASTIC MATERIALS UNDER THE INFLUENCE OF ARTERIAL BLOOD FLOW IN THE CAROTID BASIN

Objective: to study morphological changes in the application of various plastic materials for inclusion of the carotid basin into arterial blood flow. Material and methods. The study was performed on experimental animals. 15 mongrel dogs underwent surgery. The average weight was 23 ± 2 kg. All the animals were male. When conducting experimental studies we used different plastic materials; PTFE conduit was used as an artificial material, a great saphenous vein was used as a subcutaneous autovein, a femoral vein - as a deep autovein. The morphological parameters were assessed by light and electron microscopy. Statistical analysis of the results was performed using analytical package «Statistica» 6.0, the normality of feature distribution was assessed by the Shapiro Wilk test. The normality of qualitative feature distribution showed that the distribution of the parameters differed from the normal (p < 0,001), therefore the comparative analysis of the groups was performed using the methods of parametric statistics. For the comparative description of the features, nonparametric methods of research were used: comparison of two independent selections - Mann - Whitney U-test. In presenting of figure values the median was used (Ме), percentile 25 and 75: Ме (25 %, 75 %). The level of statistical significance was taken as р < 0.05. Results. The morphological study of plastic materials is also associated with the assessment of the function of vascular prostheses. At the same time, great importance is attached to the microvasculature of the vessel walls. Morphometric method of research plays an important role in the study of morphological and functional features of patches. The application of the femoral vein as a plastic material is of particular interest. Conclusion. 12 months after the start of the experiment the greatest wall thickness patch was identified when using the femoral vein, which reflects the optimal adaptation to the blood flow. The degree of vascularization was detected when using the femoral vein, which favorably influences the operation of this type of plastic material.

морфология, вены, артерии, пластические материалы, эндартерэктомия, morphology, veins, arteries, plastic materials, endarterectomy

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