Preview

Проблемы здоровья и экологии

Расширенный поиск

ЛЕЧЕНИЕ РЕЦИДИВОВ И РЕФРАКТЕРНЫХ ФОРМ ОСТРЫХ МИЕЛОИДНЫХ ЛЕЙКОЗОВ

https://doi.org/10.51523/2708-6011.2014-11-4-15

Аннотация

Обзор посвящен рецидивам и рефрактерным формам острых миелоидных лейкозов, которые являются гетерогенными заболеваниями и не имеют универсальной единой терапевтической схемы. В статье дана характеристика протоколов с включением новых агентов, показана роль аллогенной трансплантации гемопоэтических стволовых клеток, систематизированы достижения в стратификации риска для лечения острых миелоидных лейкозов. Определена перспектива персонализации терапии с учетом молекулярных тестов. Показано гарантированное снижение частоты рецидивов при использовании более эффективных индукционных и постремиссионных протоколов.

Об авторах

Д. И. Суворов
Республиканский научно-практический центр радиационной медицины и экологии человека, г. Гомель Белорусская медицинская академия последипломного образования, г. Минск
Беларусь


Н. Н. Климкович
Республиканский научно-практический центр радиационной медицины и экологии человека, г. Гомель Белорусская медицинская академия последипломного образования, г. Минск
Беларусь


Список литературы

1. Forman, S. J. The myth of the second remission of acute leukemia in the adult / S. J. Forman, J. M. Rowe // Blood. - 2013. - Vol. 121(7). - P. 1077-1082.

2. Ofran, Y. Treatment for relapsed acute myeloid leukemia: what is new? / Y. Ofran, J. M. Rowe // Curr Opin Hematol. - 2012. - Vol. 19. - P. 89-94.

3. The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenetic subgroups / C. Schoch [et al.] // Haematologica. - 2004. - Vol. 89(9). - P. 1082-1090.

4. Estey, E. H. Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management / E. H. Estey // Am J Hematol. - 2012. - Vol. 87(1). - P. 89-99.

5. The European Leukemia Net AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach / J. Cornelissen [et al.] // Nat Rev Clin Oncol. - 2012. - Vol. 9(10). - P. 579-590.

6. Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse / S. Kurosawa [et al.] // Haematologica. - 2010. - Vol. 95. - P. 1857-1864.

7. A new Leukemia Prognostic Scoring System for refractory/ relapsed adult acute myelogeneous leukaemia patients: a GOELAMS study / P. Chevallier [et al.] // Leukemia. - 2011. - Vol. 25. - P. 939-944.

8. Juliusson, G. Most 70- to 79-year-old patients with acute myeloid leukemia do benefit from intensive treatment / G. Juliusson // Blood. - 2011. - Vol. 117. - P. 3473-3474.

9. Rowe, J. M. How I treat acute myeloid leukemia / J. M. Rowe, M.S. Tallman // Blood. - 2010. - Vol. 116. - P. 3147-3156.

10. Failure of three novel regimens to improve outcome for patients with relapsed or refractory acute myeloid leukaemia: a report from the Eastern Cooperative Oncology Group / M. R. Litzow [et al.] // Br J. Haematol. - 2010. - Vol. 148. - P. 217-225.

11. Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure / M. Duval [et al.] // J. Clin. Oncol. - 2010. - Vol. 28. - P. 3730-3738.

12. Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation / C. Schmid [et al.] // Blood. - 2006. - Vol. 108. - P. 1092-1099.

13. A phase II trial of sequential treatment with cytoreductive therapy and reduced intensity conditioning allogeneic stem cell transplantation for relapsed/refractory acute myeloid leukaemia, high-risk MDS and other high risk myeoid malignancies: an interim report / D. A. Tsitsikas [et al.] // Blood. - 2010. - Vol. 116. - P. 3480a.

14. Alternative donors hematopoietic stem cells transplantation for adults with acute myeloid leukemia: umbilical cord blood or haploidentical donors? / A. Ruggeri [et al.] // Best Pract Res Clin Haematol. - 2010. - Vol. 23. - P. 207-216.

15. Auto-SCT for AML in second remission: CALGB study 9620 / C. A. Linker [et al.] // Bone Marrow Transplant. - 2009. - Vol. 44. - P. 353-359.

16. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy / A. K. Burnett [et al.] // J Clin Oncol. - 2010. - Vol. 28. - P. 2389-2395.

17. Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukemia / P. S. Becker [et al.] // Br J Haematol. - 2011. - Vol. 155. - P. 182-189.

18. Faderl, S. Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia / S. Faderl, V. Gandhi, H. M. Kantarjian // Curr Opin Hematol. - 2008. - Vol. 15. - P. 101-107.

19. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse / M. Levis [et al.] // Blood. - 2011. - Vol. 117. - P. 3294-3301.

20. Treatment of FLT3-ITD-positive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib / M. Sharma [et al.] // Biol Blood Marrow Transplant. - 2011. - Vol. 17. - P. 1874-1877.

21. A phase II open-label, AC220 monotherapy efficacy (ACE) study in patients with acute myeloid leukemia (AML) with FLT3-ITD activating mutations: interim results / J. Cortes [et al.] // Haematologica. - 2011. - Vol. 96. - P. 1019a.

22. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukemia / C. C. Smith [et al.] // Nature. - 2012. - Vol. 485. - P. 260-263.

23. Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes / J. K. Lamba [et al.] // Pharmacogenomics. - 2011. - Vol. 12. - P. 327-339.

24. A phase Ib study combining the mTOR inhibitor everolimus (RAD001) with low-dose cytarabine in untreated elderly AML / A. H. Wei [et al.] // Blood. - 2010. - Vol. 116. - P. 3299a.

25. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia / P. Fenaux [et al.] // J. Clin. Oncol. - 2010. - Vol. 28. - P. 562-569.

26. -Azacytidine for the treatment of patients with acute myeloid leukemia or myelodysplastic syndrome who relapse after allo-SCT: a retrospective analysis / A. Czibere [et al.] // Bone Marrow Transplant. - 2010. - Vol. 45. - P. 872-876.

27. Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial / U. Platzbecker [et al.] // Leukemia. - 2012. - Vol. 26(3). - P. 381-389.

28. Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia / A. D. Schimmer [et al.] // J. Clin. Oncol. - 2009. - Vol. 27. - P. 4741-4746.

29. Katragadda, L. XIAP antisense therapy with AEG 35156 in acute myeloid leukemia / L. Katragadda, B. Z. Carter, G. Borthakur // Expert Opin Investig Drugs. - 2013. - Vol. 22(5). - P. 663-670.

30. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms’ tumor 1 antigen-targeted dendritic cell vaccination / V. F. Van Tendeloo [et al.] // Proc Natl Acad Sci USA. - 2010. - Vol. 107. - P. 13824-13829.

31. Lin, Ch. The role of peptide and DNA vaccines in myeloid leukemia immunotherapy / Ch. Lin, Y. Li //Cancer Cell International. - 2013. - Vol. 13. - 7 p.

32. Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients / M. Guo [et al.] // Blood. - 2011. - Vol. 117. -P. 936-941.


Рецензия

Для цитирования:


Суворов Д.И., Климкович Н.Н. ЛЕЧЕНИЕ РЕЦИДИВОВ И РЕФРАКТЕРНЫХ ФОРМ ОСТРЫХ МИЕЛОИДНЫХ ЛЕЙКОЗОВ. Проблемы здоровья и экологии. 2014;(4):75-80. https://doi.org/10.51523/2708-6011.2014-11-4-15

For citation:


Suvorov D.I., Klimkovich N.N. THE TREATMENT FOR RELAPSED AND REFRACTORY FORMS OF ACUTE MYELOID LEUKEMIA. Health and Ecology Issues. 2014;(4):75-80. (In Russ.) https://doi.org/10.51523/2708-6011.2014-11-4-15

Просмотров: 242


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)