THE EFFECT OF TOXIGENIC STRAINS OF HELICOBACTER PYLORI ON CLINICAL AND MORPHOLOGICAL MANIFESTATIONS OF CHRONIC GASTRODUODENAL PATHOLOGY IN CHILDREN
https://doi.org/10.51523/2708-6011.2014-11-3-20
Abstract
Objective: to study the incidence rate of different genotypes of Helicobacter pylori in children with erosive and ulcerative changes in gastric and duodenum mucosa, as well as to evaluate the effect of toxigenic strains on the morphological changes of the mucosa. Material of study. 230 children aged from 8 to 17 with chronic gastroduodenal pathology associated with Helicobacter pylori were examined. Results. The examined patients revealed the heterogeneity of Helicobacter pylori genome. The persistence of toxigenic strains of Helicobacter pylori is associated with the expressed morphological changes in the mucous membrane. Conclusion. The development of the erosive and ulcerative processes in the stomach and duodenum mucosa in children is associated with the persistence of virulent strains of Helicobacter pylori infection with cagA+vacAs1/m1 or cagA+vacAs1s2/m1m2 genotypes.
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Review
For citations:
Nalyotov A.V. THE EFFECT OF TOXIGENIC STRAINS OF HELICOBACTER PYLORI ON CLINICAL AND MORPHOLOGICAL MANIFESTATIONS OF CHRONIC GASTRODUODENAL PATHOLOGY IN CHILDREN. Health and Ecology Issues. 2014;(3):103-107. (In Russ.) https://doi.org/10.51523/2708-6011.2014-11-3-20
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