The Response of Tumor Microenvironment to Radiation Therapy: Analysis of the Disease-Free Survival of Patients with Endometrioid Adenocarcinoma of the Corpus Uteri
https://doi.org/10.51523/2708-6011.2019-16-4-7
Abstract
Objective: to identify the threshold values of FoxP3, CD56, PGRMC1, and Galectin-1 expression, to analyze the survival rate of female patients based on the obtained threshold values, to determine the statistical differences in groups depending on the presence/absence of radiotherapy.
Mаteriаl аnd methods. The group with radiotherapy (LT+) included 42 female patients, the group without radiotherapy (LT-) included 38. The ROC-analysis was performed to determine the threshold values. The analysis of the survival rate was performed using the logrank test. The groups were compared using the tables 2×2 (Fisher's twosided test), as well as the odds ratio (OR) was calculated. The differences were considered statistically significant at p < 0.05.
Results. The study of the Galectin-1 parenchymatous expression showed that statistically significant differences (p<0.0001) were revealed in the study of the relapsefree survival rate based on the obtained threshold value. Gamma ray therapy reduced the parenchymatous expression of Galectin-1 below the threshold value (OR = 0.490 95% CI 0.288-0.800). The analysis of the relapsefree survival rate on the basis of the obtained threshold value of the stromal expression of Galectin-1 revealed statistically significant differences (p = 0.0002). Gamma ray therapy reduced the stromal expression of Galectin-1 below the threshold value (OR = 0.289 95 % CI 0.112-0.742).
Conclusion. At a low relapsefree survival rate, a statistically significant increase above the threshold values of the parenchymatous (p < 0.0001) and stromal (p = 0.0002) Galectin-1 expression was observed most frequently.
About the Authors
D. A. Zinovkin
Gomel State Medical University
Belarus
Belarus
Zinovkin D.A., assistant of the Department of Pathologic Anatomy of the EI «Gomel State Medical University».
E. A. Nadyrov
Gomel State Medical University
Belarus
Belarus
Nadyrov E.A. PhD, Associate Professor, Department of Histology, Cytology and Embryology of the EI «Gomel State Medical University».
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Review
For citations:
Zinovkin D.A., Nadyrov E.A. The Response of Tumor Microenvironment to Radiation Therapy: Analysis of the Disease-Free Survival of Patients with Endometrioid Adenocarcinoma of the Corpus Uteri. Health and Ecology Issues. 2019;(4):38-43. (In Russ.) https://doi.org/10.51523/2708-6011.2019-16-4-7
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