DRUGS AS INDUCERS OF STEVENS-JOHNSON SYNDROME - TOXIC EPIDERMAL NECROLYSIS IN CHILDREN
https://doi.org/10.51523/2708-6011.2014-11-3-1
Abstract
The review presents causes and clinical features of Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), in children and analyzes the role of drugs as inducers of the illness. The high risk of SJS/TEN in children is associated with co-trimoxazol (sulfamethoxazol + trimethoprim), other anti-infective sulfonamides, anticonvulsants (phenobarbital, carbamazepin, lamotrigine), non-steroidal anti-inflammatory drugs of the oxicam-type. The highest risk of SJS/TEN development occurs during the first eight weeks of treatment with a subsequent sharp decrease in the incidence rate. Certain genetic factors contribute to SJS/TEN development.
About the Authors
T. P. Dyubkova
Belarusian State University, Minsk
Belarus
Belarus
V. F. Zhernosek
Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus
Belarus
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Review
For citations:
Dyubkova T.P., Zhernosek V.F. DRUGS AS INDUCERS OF STEVENS-JOHNSON SYNDROME - TOXIC EPIDERMAL NECROLYSIS IN CHILDREN. Health and Ecology Issues. 2014;(3):7-15. (In Russ.) https://doi.org/10.51523/2708-6011.2014-11-3-1
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