EFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTS
https://doi.org/10.51523/2708-6011.2014-11-2-7
Abstract
Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %, 19,4 and 41,7 %, respectively) (p = 0,076, LR = 0,313, 95 % DI = 0,084-1,164 for DD and p = 0,266, LR = 0,631, 95 % DI = 0,303-1,312 for D). Conclusion. The comparison of the results of genotyping in patients with and without DN did not reveal any differences in distribution of allele and ACE genotypes.
About the Authors
O. N. Vasilkova
Gomel State Medical University
Belarus
Belarus
A. E. Silin
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
V. N. Martinkov
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
I. B. Tropashko
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
K. K. Zekenova
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
M. V. Zhmailik
Republican Research Centre for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
T. V. Mokhort
Belarusian State Medical University, Minsk
Belarus
Belarus
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Review
For citations:
Vasilkova O.N., Silin A.E., Martinkov V.N., Tropashko I.B., Zekenova K.K., Zhmailik M.V., Mokhort T.V. EFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTS. Health and Ecology Issues. 2014;(2):35-40. (In Russ.) https://doi.org/10.51523/2708-6011.2014-11-2-7
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