BACTERICIDAL PROPERTIES OF FLUOROQUINOLONE-CONTAINING EYE DROPS

Abstract

Goal: to find out antimicrobial efficacy of ophthalmologic drugs containing fluoroquinolons of II-III generations. Material and methods. Minimal inhibitory concentrations for isolates of Staphylococcus aureus and Pseudomonas aeruginosa were determined for four drugs containing fluoroquinolons of II-III generations. The kinetics of growth and dying off of the test-culture of Pseudomonas aeruginosa ATCC 27853 under different fluoroquinolon concentration were performed in nutrient broth medium. Results. The minimal inhibitory concentrations for various drugs ranged from 0,125 to 1,0 mcg/ml. In relation to the test-cultures of Staphylococcus aureus , III generation fluoroquinolones (levofloxacin MIC 0,25-0,5 mcg/ml) were the most active. Ciprofloxacin was the most active against Pseudomonas aeruginosa (MIC 0,125 mcg/ml). It was shown that the bacterial effect of all the fluoroquinolones depends directly on the concentration of antibiotic in the medium. Conclusion. The antimicrobial activity of II-III generation fluoroquinolones from different producers was similar. The concentration of fluoroquinolones in the studied drugs makes it possible to achieve the bactericidal effect for sensitive gram-negative strains, even after short-term exposure. It is preferable to use III generation fluoroquinolones to treat for infections caused by gram-positive microorganisms