THE EFFECT OF SOY MILK DIET ON THE STRUCTURAL AND FUNCTIONAL STATUS OF RATS COLON DURING MONOSODIUM GLUTAMATE TREATMENT

Abstract

Objective: to study the effect of soy milk diet on the structural and functional status of rats colon during the monosodium glutamate (MSG) treatment. Materials and methods . The experiments were performed on male white outbred rats with the initial body mass of 144,3 ± 1,72 g (n = 49). The dose of monosodium glutamate was calculated by the following scheme - 0,5 % per kg of the product the guests according to Sanitary Regulations and Norms of November 28 2002 No.94, the dose of soy milk - at a volume of 2 ml. Histological and biochemical studies were performed by standard methods. Results. One-month MSG therapy was determined to cause structural reorganization of the mucous membrane of the rats colon, violation of mucus production with goblet cells related to hyperplasia and hypertrophy, and lead to an increase in the content of sialic- and fukoglycoproteins, reduced lysozyme activity. The introduction of soy milk into the diet during treatment with sodium glutamate is accompanied by restoration of the wall structure of the colon, normalization of goblet cells «work», decreased levels of sialic acid and fucose in their secretion, increased activity of lysozyme. Conclusion. The introduction of soy milk into the diet eliminates the negative effect of the MSG therapy: restores the structure of the mucous membrane of the rats colon, promotes its protective function and contributes to the natural resistance of the organism.