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ИММУНОФЕНОТИПИЧЕСКАЯ ДИФФЕРЕНЦИРОВКА КЛЕТОК КОСТНОГО МОЗГА В ДИАГНОСТИКЕ ПЕРВИЧНЫХ МИЕЛОДИСПЛАСТИЧЕСКИХ СИНДРОМОВ

https://doi.org/10.51523/2708-6011.2014-11-1-9

Abstract

The analysis of recent achievements in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow points to a significant role of flow cytometry in the diagnosis of myelodysplastic syndromes. The research revealed the MDS-associated phenotype of blast cells in de novo myelodysplastic syndromes. The standardization of flow cytometry analysis in myelodysplastic syndromes may thus improve the diagnosis of these diseases.

About the Authors

V. V. Smolnikova
Municipal Clinical Hospital No. 9, Minsk Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus


N. N. Klimkovich
Municipal Clinical Hospital No. 9, Minsk Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus


T. V. Lebedeva
Municipal Clinical Hospital No. 9, Minsk Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus


V. Y. Grinevich
Municipal Clinical Hospital No. 9, Minsk Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus


A. V. Bakun
Municipal Clinical Hospital No. 9, Minsk Belarusian Medical Academy of Post-Graduate Education, Minsk
Belarus


References

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2. NCCN Practice guidelines in Oncology Myelodysplastic syndromes v.2.2008. http://www.nccn.org/professionals/physician gls/PDF/mds.pdf.

3. Valent, P. Minimal diagnostic criteria for myelodysplastic syndromes and separation from ICUS and IDUS: update and open questions / P. Valent, H.-P. Horny // Eur J Clin Invest. - 2009. - Vol. 39 (7). - P. 548-553.

4. Stetler-Stevenson, M. Myelodysplastic syndromes: the role of flow cytometry in diagnosis and prognosis / M. Stetler-Stevenson, C. M. Yuan // International Journal of Laboratory Hematology. - 2009. - Vol. 31, № 5. - Р. 479-483.

5. Flow cytometry in myelodysplastic syndromes: report from a working conference / M. R. Loken [et al.] // Leuk. Res. - 2008. - Vol. 32. - P. 5-17.

6. Myelodysplastic syndromes/neoplasms, overview / R. D. Brunning [et al.] / In: S.H. Swerdlow et al. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissuesl // Lyon: IARC. - 2008. - Vol. 2. - P. 88-93.


Review

For citations:


Smolnikova V.V., Klimkovich N.N., Lebedeva T.V., Grinevich V.Y., Bakun A.V. . Health and Ecology Issues. 2014;(1):51-56. (In Russ.) https://doi.org/10.51523/2708-6011.2014-11-1-9

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ISSN 2220-0967 (Print)
ISSN 2708-6011 (Online)