PHARMAECONOMIC ANALYSIS OF APPLICATION RATIONALITY OF REAGENTS FOR DIAGNOSIS AND DRUGS FOR TARGET THERAPY OF GASTROINTESTINAL STROMAL TUMORS

Abstract

Objective: The comparative study of gastrointestinal stromal tumors in Gomel and Vitebsk regions and pharmacoeconomic analysis of the effectiveness of immunohistochemical reagents used for detection of gastrointestinal stromal tumors (CD-117) and the targeted medication Imatinib (Glivec) for treatment of inoperable forms of these tumors. Materials and Methods. We used archival material for the period 2010-2011. The clinical and morphological analysis of CD 117 expression was conducted in human mesenchymal tumors of the gastrointestinal tract. The rationality of the use of reagents for diagnosis of gastrointestinal stromal tumors and drugs for targeted therapy was evaluated on the invoices for the purchase of the reagents and the drug Imatinib (Glivec). The morphological parameters were assessed by the light optical microscope «CarlZeiss» Axioscop 40 with an increase of 100, 200 and 400. The results of the study were statistically analyzed using the analytical package «Statistica» 6.0. Results. The incidence of gastrointestinal stromal tumors and the patient age correspond to the published data for other countries with their more frequent diagnosis in Gomel region. In addition, the excess procurement of antibodies to CD-117 is observed in the studied regions.