Comparative Characteristics of CLINICAL and LABORATORY FEATURES of SECONDARY and DE NOVO acute myeloid leukemia in children
https://doi.org/10.51523/2708-6011.2012-9-4-16
Abstract
Secondary leukemias in children in most cases are acute myeloid leukemia (AML) cases induced by chemotherapy and/or radiotherapy and by other chemical mutagens after treatment of malignant neoplasms (MN) or acquired aplastic anemia (AAA). The purpose of this study was to evaluate the clinical and laboratory features of secondary AML. The study included 9 patients with secondary AML and 128 patients with de novo AML. The girls revealed secondary AML more often. The largest percentage of secondary AML cases was observed in the age group from 3 to 10 (age median: 11.5), the most frequently registered morphology was M1-M2, but statistically significant differences with de novo AML were not found (p > 0,05). When comparing the clinical manifestations, no significant differences were detected (p > 0,5). Meanwhile, the pathology of chromosome 7 with secondary AML was significantly the most prevalent (p ≤ 0,01).
About the Authors
I. P. Romashevskaya
Republican Research Center for Radiation Medicine and Human Ecology, Gomel
Belarus
Belarus
N. N. Savva
Republican Research Center for Pediatric Oncology, Hematology and Immunology, Minsk
Belarus
Belarus
N. P. Litvinko
Republican Research Center for Pediatric Oncology, Hematology and Immunology, Minsk
Belarus
Belarus
O. V. Aleinikova
Republican Research Center for Pediatric Oncology, Hematology and Immunology, Minsk
Belarus
Belarus
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Review
For citations:
Romashevskaya I.P., Savva N.N., Litvinko N.P., Aleinikova O.V. Comparative Characteristics of CLINICAL and LABORATORY FEATURES of SECONDARY and DE NOVO acute myeloid leukemia in children. Health and Ecology Issues. 2012;(4):83-88. (In Russ.) https://doi.org/10.51523/2708-6011.2012-9-4-16
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