INFLUENCE OF OXYTOCIN ON THE REORGANIZATION OF THE CONNECTIVE TISSUE OF THE PANCREATIC PCEUDOCYST WALL

Abstract

Objective. To estimate the influence of oxytocin on the reorganization of the connective tissue of the pancreatic pseudocyst wall after its emptying by punctural aspiration. Materials and methods. The experimental research was performed on 62 white rats. The pseudocyst of the pancreas was modeled with help of cryosurgical complex KCH 3A/B. The punctural aspiration of the contents of the pseudocyst was carried out on the fourteenth day after the cryoexposure with introduction 1 I.U. of oxytocin in its cavity. Histological research was performed with use of morphometry. The changes in the morphometric parameters of the pancreatic pseudocyst and quantitative contents of neutrophils, lymphocytes, macrophages and fibroblasts were estimated. Results. The application of oxytocin led to increased numbers of macrophages and fibroblasts and reduction of neutrophiled leucocytes starting from the third day and lymphocytes from the seventh day of the experiment. The study revealed the progressive reduction the sizes of the pseudocyst which ended in its involution. Conclusion. The local use of oxytocin in the punctural aspiration of the pseudocyst contents significantly stimulates proliferation of fibroblasts and macrophages and causes complete involution of the pseudocyst of the pancreas.