CLINICAL EFFICACY OF ACTOVEGIN IN COMPLEX THERAPY OF CORONORARY HEART DISEASE

Objective. To determine clinical efficacy of the preparation «Aсtovegin», included in the complex therapy of patients with CHD. Material and methods. The research included patients aged from 30 to 60 with ischemic heart disease, i.e. stable stenocardia of I-III functional classes (chronic heart insufficiency of I-III functional classes according to NYHA classification and/or portinfarction cardiosclerosis). The average age at the moment of the examination was 55,03 ± 0,53. A total of 243 patients were examined, and of them, 216 patients were treated with aсtovegin. The statistic data were processed with the use of the standard set of statistic programs «Statistica», 6,0 (StatSoft, USA). Results. An earlier stabilization of stenocardia and relatively greater level of readaptation to physical activities as well as decrease of ejection fraction (EF) were observed in the patients treated with actovegin. The analysis of the biochemical blood values revealed that the treatment with this preparation led to a significant decrease in cholesterol, low- and very low-density lipoproteids. Conclusion. Actovegin in the complex therapy of patients with CHD stimulates contractile ability of cardiac muscle, has a positive effect on cardiac pumping function. Possessing an antihypoxic, insulin-like, cytoprotective and reperative effects, it corrects tissue metabolism, at the same time improving the biochemical blood values in the patients with CHD.

болезни системы кровообращения, ишемическая болезнь сердца, лечение, актовегин, критерии эффективности, diseases of blood circulation system, ischemic heart disease, treatment, actovegin, efficacy criteria

1. Окороков, Н. А. Лечение болезней внутренних органов: в 3 т. / Н. А. Окороков. - Минск: Медицинская литература, 1997 г. - Т.3, кн.1: Лечение болезней сердца и сосудов. - 464 с.

2. Антигипоксанты и антиоксиданты в кардиологической практике / А. М. Шилов // РМЖ. - 2004. - Т. 12, № 2. -С. 18-24.

3. Место антиоксидантов в комплексной терапии пожилых больных ИБС / И. В. Неверов // РМЖ. - 2001. - Т. 9, № 18. - С. 38-42.

4. Свободнорадикальные перекисные механизмы патогенеза ишемии и ИМ и их фармакологическая регуляция / А. Х. Коган [и др.] // Патофизиология. - 1992. - № 2. - С. 5-15.

5. Бояринов, А. П. Метаболические эффекты нейротропного действия актовегина в условиях гипоксии. Актовегин. Новые аспекты клинического применения / А. П. Бояринов, А. А. Пенкнович, Н. В. Мухина - М.: МЕДПРАКТИКА-М, 2002. - 85 с.