ROLE OF AQUAPORIN-DEPENDENT MEMBRANE-TRANSPORT MECHANISMS IN THE REGULATION OF ERYTHROCYTE STRUCTURAL FUNCTIONAL CHARACTERISTICS IN ANEMIAS OF VARIOUS GENESIS

The participation of aquaporin-1 (AQP-1) in the regulation of erythrocyte structural metabolic features in anemias of various genesis has been studied. It has been ascertained that the patients with asiderotic anemia (n = 6) have a 36 per cent decrease in the erythrocyte aggregation speed in comparison with the control group (n = 12). AQP-1 inhibition and AQP-1 combined suppression and phospholipase-dependent membrane mechanisms lead the increase in the erythrocyte aggregation speed till the level of the control group. The received results are evidence of AQP-1 participation in the regulation of erythrocyte structural metabolic features in the patients with anemias.

аквапорин-1, эритроциты, средний объем эритроцита, средняя концентрация гемоглобина, агрегационная активность эритроцитов, анемия, aquaporin-1, erythrocytes, mea corpuscular volume, mean hemoglobin concentration, erythrocyte aggregation activity, anemia

1. Смирнова, Л. А. Анемии: диагностика, клиника, лечение: Монография / Л. А. Смирнова. - Минск: БГЭУ, 2002. - 98 с.

2. Титовец, Э. П. Аквапорины человека и животных: фундаментальные и клинические аспекты / Э. П. Титовец. - Минск: Белорус. наука, 2007. - 239 с.

3. Aquaporin CHIP: the archetypal molecular water channel / P. Agre [et al.]. // American Journal of Physiology. Renal Physiology. - 1993. - № 265. - Р. 463-476.

4. Aquaporin water channels - from atomic structure to clinical medicine / P. Agre [et al.] // Journal of Physiology. - 2002. - № 542. - Р. 3-16.

5. Blank, M. E. Aquaporin-1 and HCO3-Cl-transporter-mediated transport of CO2 across the human erythrocyte membrane / M. E. Blank, H. Ehmke // J. Physiol. - 2003. - № 550. - Р. 419-429.

6. Endeward, V. Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane / V. Endeward // FASEB J. - 2006. - Vol. 20, № 12. - P. 1974-1981.