FINDING A DONOR FOR STEM CELLS DEPENDING ON THE DISTRIBUTION OF HLA ANTIGEN SYSTEM PARAMETERS IN THE PATIENT POPULATION

Abstract

176 oncohematologic patients, their sibs and 200 blood donors were examined to determine the possibility for related and unrelated donor for hemapoietic stem cell transplantation. HLA antigens I and II were indentified and frequency of occurrence of certain parameters of this system was calculated. It was shown that the compatible sibling was most often selected in anplastic anemia (57,5 % cases) for the patients with anplastic anemia, chronic myeloleukemia (CML), acute myeloblastic leukemia (AML) and lymphogranulomatosis (LGM). The matching of a donor-sibling for the patients with three other nosologies varied from 34,4 % for LGM, up to 39,9 % cases for AML and CML took an intermediate position - 38,3%. Meanwhile the found values for the 3 later groups were not statistically different, but were reliably lower than for the patients with anplastic anemia. The revealed features in the distribution and their siblings of the HLA system parameters in comparison with the control group were the reason for more often finding a donor-sibling for the patients with anplastic anemia. The above mentioned values were identical among themselves (for the patients and siblings). On the contrary, the HLA-parameter distribution for the patients of the three other groups as in their siblings did not differ from the control groups. It has been established, that the citizens of Minsk have the Caucasian type of HLA-gene distribution. Consequently, the search for an unrelated donor for the transplantation is possible not only in the data register of the Republic of Belarus, but also in the analogous registers of other countries.