SOLUBLE FORM OF INTERLEUKIN-8 CXCR2 RECEPTOR AS A MARKER OF THE LOCAL INFLAMMATORY INVOLVEMENT OF THE HUMAN BLOOD NEUTROPHIL LEUKOCYTES

The decreased level of the chemotactical receptor CXCR2 expression is accompanied by the emergence of soluble CXCR2 (рCXCR2) in cellular supernatant in neutrophil activation. The content of рCXCR2, interleukin-6 (IL-6) and α-defenzins (human neutrophil peptides, HNP) has been studied in the peritoneal fluid of patients with acute peritonitis and lavages from abdominal cavity in diagnostic lapascopy for the diseases that are not related to the abdominal organ inflammation (control group). It was shown that the levels of рCXCR2, HNP and IL-6 in the peritoneal fluid were reliably higher in the comparison with the level of the control group in the acute postoperative period of the disease. The positive correlation between рCXCR2 and HNP (r = 0,72, р < 0,001) and IL-6 (r = 0,64, р < 0,05) was detected in the peritoneal fluid of the patients and the lavages from the abdominal cavity of the patients of the control group. We assume that the detection of рCXCR2 in the peritoneal fluid alongside with IL-6 and HNP can serve as an additional diagnostic tool for the early recognition of intra-abdominal peritonitis complications.

растворимый рецептор интерлейкина-8 CXCR2, нейтрофилы, острый перитонит, интерлейкин-6, α-дефензины, soluble interleukin-8 CXCR2 receptor, neutrophils, acute peritonitis, interleukin-6, α-defenzins