IMMUNOPHENOTYPE ABERRANCE OF MARROW CELLS IN PRIMARY MYELODYSPLASTIC SYNDROMES

Abstract

The immunophenotyping method makes it possible to detect and delimit specific cellular antigenic determinants, which enables to establish the criteria for the identification ofmorphlogically non-differetiable normal and pathologic cells. A leukemic cell clone has homogenous morphcytochemical characteristics in myelodysplastic syndromes. It is heterogenic in its antigenic structure of blastic elements which determines the prospects for its immunophenotypic investigation. The immunophenotype of marrow cells displays a high diagnostic value by the heterogeneity of the cellular population in the patients with myelodysplastic syndromes. The given method may serve as a tool for differentiative diagnosis for different myelodysplastic syndromes and can be used in the elaboration of the prognostic criteria for this pathology.