ACQUIRED ABNORMALITIES IN BLOOD COAGULATION AS A CAUSE FOR HEMORRHAGIC COMPLICATIONS IN THE STAGES OF PROGRAM TREATMENT OF CHILDREN WITH SOLID TUMORS AND LEUKEMIA

Abstract

The changes of the functional state of blood coagulation, registered in the process of the treatment of oncological patients are caused in the majority of cases by the combined defect of a plasmic component in consequence of thrombocytopenia. The reaching of a diagnostic threshold for the thrombocyte level less than 28 × 10⁹/l and factor activity of prothrombin complex less than 40 per cent as a result of the clinic of systemic inflammatory response allows of making a supposition that a bleeding develops within a few days at the early stage of the treatment of the patient with malignant neoplasm or hemoblastosis. If the number of thrombocytes is more than 28,5 × 10⁹/l /l in the combination with the level of factor activity of the prothrombin complex no less than 40 per cent or there is no systemic inflammatory response syndrome, the changes of blood coagulation cannot be an independent cause for a bleeding and the correction is not needed.