CLINICAL DIAGNOSTIC SIGNIFICANCE OF FAS/APO-1(CD-95)-ANTIGEN IN HIV- INFECTION
https://doi.org/10.51523/2708-6011.2011-8-4-14
Abstract
As a result of the examination of 83 HIV-positive patients it has been established, that HIV-infection reveals higher levels and higher optical density of sFas/Apo-1(CD-95)-antigen in blood serum in comparison with those in practically healthy donors. The patients in AIDS stage detect higher average levels of optical density of sFas/Apo-1 (CD-95)-antigen in the blood serum, than the patients out of the AIDS stage. The average optical density levels and frequency of revealing the increased optical density levels of sFas/Apo-1(CD-95)-antigen in the blood serum are significantly higher in the HIV-positive patients with number of CD4+T-lymphocytes less than 200 in 1 mkl in the blood, than in the patients with that more than 200 in 1 mkl. The increased optical density levels оf sFas/Apo-1(CD-95)-antigen are defined in the HIV-positive patients only in the development of moderate and expressed immune suppression (CD4 < 350 cells/mkl) and directly moderately correlate with a clinical stage of HIV infection.
About the Authors
N. V. Moskaliova
Belarussian Medical Academy for Postgraduate Education, Minsk
Belarus
Belarus
S. V. Zhavoronok
Belarussian Medical Academy for Postgraduate Education, Minsk
Belarus
Belarus
O. L. Tumash
Gomel State Medical University
Belarus
Belarus
A. Yu. Baryshnikov
Gomel Regional Clinical Infectious Hospital
Belarus
Belarus
V. V. Karmazin
Russian Oncologic Research Center named after N. N.Blokhina of the Russian Academy of Medical Sciences, Moscow
Belarus
Belarus
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Review
For citations:
Moskaliova N.V., Zhavoronok S.V., Tumash O.L., Baryshnikov A.Yu., Karmazin V.V. CLINICAL DIAGNOSTIC SIGNIFICANCE OF FAS/APO-1(CD-95)-ANTIGEN IN HIV- INFECTION. Health and Ecology Issues. 2011;(4):79-83. (In Russ.) https://doi.org/10.51523/2708-6011.2011-8-4-14
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