IMMUNOGLOBULIN AND CYTOKINE CONCENTRATIONS IN CHILDREN WITH BRONCHIAL ASTHMA AND THEIR CORRELATIONS IN AUTOSERUM THERAPY

Abstract

This article presents the results of clinical and immunological survey of 41 children with allergic bronchial asthma (BA) before and after the treatment, including autoserum therapy. The concentrations of IgA, IgM, IgG, IgE as well as of IL-4, IL-6 and TNF-α in serum of the given patients were detected using the enzyme-linked immunosorbent assay (ELISA). The correlative relations among the immunoglobulins and cytokines have also been established. It has been determined that IgA, IgM, IgG, IgE and IL-4 correlate within their group before and after the treatment, including autoserum therapy. The groups of IgE (n = 30; r = 0,8430; p < 0,001), IL-4 (n = 41; r = 0,7626; p < 0,001) and IgM ( n = 40; r = 0,7366; p < 0,001) revealed the high degree of correlation before and after the treatment. The majority of correlation interactions were observed in IgA group. The IL-6 and TNF-α groups revealed a certain correlative relation before and after the treatment, including autoserum therapy. However, before and after the treatment in the range of their group there was an unreliable correlation (p > 0,05), which could have been caused by concomitant pathology, accompanied by the activation of inflammation in a number of the patients with bronchial asthma.