COMPARATIVE EVALUATION IDENTIFICATION OF INFLAMMATORY BOWEL DISEASE AND TUMOR ON THE BASIS OF LACTOFERRIN AND CALPROTECTIN

The study was a comparative evaluation of the identification of inflammatory bowel disease and tumor on the basis of fecal lactoferrin and fecal calprotectin. 40 patients with colorectal cancer, 52 patients with ulcerative colitis, 45 patients with irritable bowel syndrome and 19 healthy volunteers are included in study group. Diagnoses were exposed on the basis of clinical, laboratory, endoscopic and morphological data. Healthy volunteers had no symptoms of bowel disease and were not subjected to abdominal surgical interventions. Active ulcerative colitis was assessed by an index Schroeder (Mayo Clinic UC DAI). Lactoferrin was determined in stool samples taken from a stool, enzyme immunoassay (ELISA) using kits ELISA TEST KIT Hycult Biotechnology (Netherlands). Calprotectin were determined in stool samples of patients taken from a stool, immunnofermentnym analysis using a standard set of firm «Nova Tec Immundiagnostica GmbH», Germany. Established that the diagnostic value of faecal calprotectin in the diagnosis of colorectal cancer (AUC: 0,945 ± 0,0262) and ulcerative colitis (AUC: 0,893 ± 0,032) did not differ from lactoferrin (p = 0,9547 and p = 0,9645 respectively). In the differential diagnosis of organic and functional bowel disease markers also had no reliable statistical differences on this parameter (AUC: 0,938 ± 0,0207; p = 0,8124).

язвенный колит, неинвазивная диагностика, фекальный калпротектин, фекальный лактоферрин, колоректальный рак, иммунохимический тест на скрытую кровь в кале, ulcerative colitis, non-invasive diagnostic, faecal calprotectin, faecal lactoferrin, colorectal cancer, immunochemical test for occult blood in feces

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